The role of m6A RNA methylation in cancer metabolism

Y An, H Duan - Molecular cancer, 2022 - Springer
Metabolic reprogramming is one of the main characteristics of malignant tumors, which is
due to the flexible changes of cell metabolism that can meet the needs of cell growth and …

m6A modification: recent advances, anticancer targeted drug discovery and beyond

LJ Deng, WQ Deng, SR Fan, MF Chen, M Qi, WY Lyu… - Molecular cancer, 2022 - Springer
Abstract Abnormal N6-methyladenosine (m6A) modification is closely associated with the
occurrence, development, progression and prognosis of cancer, and aberrant m6A …

The role of m6A modification in the biological functions and diseases

X Jiang, B Liu, Z Nie, L Duan, Q Xiong, Z Jin… - Signal transduction and …, 2021 - nature.com
Abstract N6-methyladenosine (m6A) is the most prevalent, abundant and conserved internal
cotranscriptional modification in eukaryotic RNAs, especially within higher eukaryotic cells …

Histone lactylation drives oncogenesis by facilitating m6A reader protein YTHDF2 expression in ocular melanoma

J Yu, P Chai, M Xie, S Ge, J Ruan, X Fan, R Jia - Genome biology, 2021 - Springer
Background Histone lactylation, a metabolic stress-related histone modification, plays an
important role in the regulation of gene expression during M1 macrophage polarization …

Targeting the RNA m6A modification for cancer immunotherapy

X Li, S Ma, Y Deng, P Yi, J Yu - Molecular cancer, 2022 - Springer
Abstract N 6-methyladenosine (m6A) is the most abundant epigenetic modification of RNA,
and its dysregulation drives aberrant transcription and translation programs that promote …

m6A modification in coding and non-coding RNAs: roles and therapeutic implications in cancer

H Huang, H Weng, J Chen - Cancer cell, 2020 - cell.com
N 6-Methyladenosine (m 6 A) RNA modification has emerged in recent years as a new layer
of regulatory mechanism controlling gene expression in eukaryotes. As a reversible …

HIF-1α-induced expression of m6A reader YTHDF1 drives hypoxia-induced autophagy and malignancy of hepatocellular carcinoma by promoting ATG2A and ATG14 …

Q Li, Y Ni, L Zhang, R Jiang, J Xu, H Yang… - Signal transduction and …, 2021 - nature.com
Abstract N6-methyladenosine (m6A), and its reader protein YTHDF1, play a pivotal role in
human tumorigenesis by affecting nearly every stage of RNA metabolism. Autophagy …

The m6A reader YTHDF1 promotes ovarian cancer progression via augmenting EIF3C translation

T Liu, Q Wei, J Jin, Q Luo, Y Liu, Y Yang… - Nucleic acids …, 2020 - academic.oup.com
Abstract N 6-Methyladenosine (m6A) is the most abundant RNA modification in mammal
mRNAs and increasing evidence suggests the key roles of m6A in human tumorigenesis …

[HTML][HTML] N6-methyladenosine modification regulates ferroptosis through autophagy signaling pathway in hepatic stellate cells

M Shen, Y Li, Y Wang, J Shao, F Zhang, G Yin, A Chen… - Redox biology, 2021 - Elsevier
Ferroptosis is a recently identified non-apoptotic form of cell death characterized by iron-
dependent lipid peroxidation. However, the underlying exact mechanisms remain poorly …

Role of m6A writers, erasers and readers in cancer

Z Fang, W Mei, C Qu, J Lu, L Shang, F Cao… - … Hematology & Oncology, 2022 - Springer
Abstract The N (6)-methyladenosine (m6A) modification is the most pervasive modification of
human RNAs. In recent years, an increasing number of studies have suggested that m6A …