Since the first TRP ion channel was discovered in Drosophila melanogaster in 1989, the
progress made in this area of signaling research has yielded findings that offer the potential …

Down syndrome (DS), affecting 1/700 live births, is the major genetic cause of mental
retardation (MR), a cognitive disorder with hard impact on public health. DS brain is …

Schizophrenia is a complex disease, likely to be caused by a combination of serial
alterations in a number of genes and environmental factors. The dorsolateral prefrontal …

J. Neurochem.(2012) 120, 440–452. Abstract Intracellular deposition of fibrillar aggregates
of α‐synuclein (αSyn) characterizes neurodegenerative diseases such as Parkinson's …

Aging is often associated with decline of memory function. Aged animals, like humans, can
naturally develop memory impairments and thus represent a useful model to investigate …

Cilia serve as sensory devices in a diversity of organisms and their defects contribute to
many human diseases. In primary cilia of kidney cells, the transient receptor potential …

Sleep is a fundamental biological process for all animals. However, the molecular
mechanisms that regulate sleep are still poorly understood. Here we report that sleep-like …

The phenotype of Down syndrome, trisomy of chromosome 21, is hypothesized to be
produced by the increased expression due to gene dosage of normal chromosome 21 …

Transplantation of neural stem cells (NSCs) improves functional outcomes following
traumatic brain injury (TBI). Previously we demonstrated that human NSCs (hNSCs) via …

Cyclic nucleotide-gated (CNG) channels encoded by the tax-4 and tax-2 genes are required
for chemosensing and thermosensing in the nematode C. elegans. We identified a gene in …