Thyroid disorders significantly affect human metabolism, cardiovascular function, skeletal
health, and reproductive systems, presenting a complex challenge due to their multifactorial …

Background SMC5/6 complex plays a vital role in maintaining genome stability, yet the
relationship with human diseases has not been described. Methods SMC5 variation was …

Aquaculture supplies the world food market with a significant amount of valuable protein.
Highly productive aquaculture fishes can be derived by utilizing genome-editing methods …

The thyroid follicular cells originate from the foregut endoderm and elucidating which genes
and signaling pathways regulate their development is crucial for understanding …

Congenital hypothyroidism (CH) is a highly prevalent but treatable neonatal endocrine
disorder. Thyroid peroxidase (TPO) catalyzes key reactions in thyroid hormone (TH) …

Context Congenital hypothyroidism (CH) is the most common endocrine disorder in
neonates, but its etiology is still poorly understood. Objective We performed whole exome …

Dual oxidase (Duox) a member of the nicotinamide adenine dinucleotide phosphate
oxidase (NOX) family can induce the production of reactive oxygen species (ROS). In …

摘要目的: 探讨smc5 基因敲除对斑马鱼肝脏基因表达谱的影响, 进一步明确smc5
突变对斑马鱼代谢的影响. 方法: 用CRISPR/Cas9 技术构建smc5 基因敲除斑马鱼模型, 取3 …

Zebrafish, a minnow family teleost fish, has emerged as a powerful in vivo vertebrate model
system in biological research. Zebrafish have been used to investigate a number of …