Extracellular matrixes (ECMs), such as the cell walls and biofilms, are important for
supporting cell integrity and function and regulating intercellular communication. These …

All microorganisms are exposed to periodic stresses that inhibit growth. Many bacteria and
fungi weather these periods by entering a hardy, nonreplicating state, often termed …

NMR spectroscopy has been applied to cells and tissues analysis since its beginnings, as
early as 1950. We have attempted to gather here in a didactic fashion the broad diversity of …

One of the challenges in clinical infectious diseases is the problem of chronic infections,
which can require long durations of antibiotic treatment and often recur. An emerging …

The ability to characterize bacterial cell-wall composition and structure is crucial to
understanding the function of the bacterial cell wall, determining drug modes of action and …

Peptidoglycan is the major structural component of the Staphylococcus aureus cell wall, in
which it maintains cellular integrity, is the interface with the host, and its synthesis is targeted …

New strategies are urgently needed to target MRSA, a major global health problem and the
leading cause of mortality from antibiotic-resistant infections in many countries. Here, we …

Metabolically quiescent bacteria represent a large proportion of those in natural and host
environments, and they are often refractory to antibiotic treatment. Such drug tolerance is …

Bacterial biofilms are complex multicellular assemblies that exhibit resistance to antibiotics
and contribute to the pathogenesis of serious and chronic infectious diseases. New …

Schrödinger's thought experiment to prepare a cat in a superposition of both alive and dead
states reveals profound consequences of quantum mechanics and has attracted enormous …