Direct interactions between proteins are essential for the regulation of their functions in
biological pathways. Targeting the complex network of protein–protein interactions (PPIs) …

Signal transduction cascades efficiently transmit chemical and/or physical signals from the
extracellular environment to intracellular compartments, thereby eliciting an appropriate …

14-3-3 proteins are a family of conserved regulatory adaptor molecules which are expressed
in all eukaryotic cells. These proteins participate in a variety of intracellular processes by …

The stabilization of protein–protein interactions (PPIs) has emerged as a promising strategy
in chemical biology and drug discovery. The identification of suitable starting points for …

The coronavirus nucleocapsid protein (N) controls viral genome packaging and contains
numerous phosphorylation sites located within unstructured regions. Binding of …

Abstract The seven 14-3-3 isoforms are highly abundant human proteins encoded by similar
yet distinct genes. 14-3-3 proteins recognize phosphorylated motifs within numerous human …

Regulation of inflammation is a central part of the maintenance of homeostasis by the
immune system. One important class of regulatory protein that has been shown to have …

3-3s represent a family of highly conserved 30 kDa acidic proteins. 14-3-3s recognize and
bind specific phospho-sequences on client partners and operate as molecular hubs to …

Raf kinases are important cancer drug targets. Paradoxically, many B-Raf inhibitors induce
the activation of Raf kinases. Cryo–electron microscopy structural analysis of a …

Degraders have illustrated that compound‐induced proximity to E3 ubiquitin ligases can
prompt the ubiquitination and degradation of disease‐relevant proteins. Hence, this …