There has been emerging interest in implementing therapeutic drug monitoring and model-
informed precision dosing of β-lactam antibiotics in critically ill patients, including children …

Meropenem, as a carbapenem antibiotic, is commonly used in critically ill pediatric patients
with severe infection because of its broad antimicrobial spectrum, high penetration into …

Objectives To compare the unbound plasma meropenem concentrations at mid-dosing
intervals (C mid, 50% fT), end-dosing intervals (C trough, 100% fT), and proportions of …

Background This study aimed to explore the effects of voriconazole on population
pharmacokinetics and optimization of the initial dose of tacrolimus in children with chronic …

This study aimed to characterize the impact of extracorporeal membrane oxygenation
(ECMO) on the pharmacokinetics (PK) of meropenem in neonates and children and to …

Background: Preterm neonates rarely participate in clinical trials, this leads to lack of
adequate information on pharmacokinetics for most drugs in this population. Meropenem is …

Background: Dosing strategies of β-lactams and vancomycin should be optimized according
to pharmacokinetic/pharmacodynamic principles. However, there is no available data …

Background Meropenem is a widely used carbapenem for treating severe pediatric
infections. However, few studies have assessed its pharmacokinetics/pharmacodynamics …

Abstract การ ติด เชื้อ แบคทีเรีย แก รม ลบ ดื้อยา หลาย ขนาน (multidrug-resistant Gram-negative
bacteria, MDR-GNB) ใน โรง พยาบาล ทำให้ ผู้ ป่วย วิกฤต มี อัตรา การ เสีย ชีวิต สูง ขึ้น นอกจาก นี้ …

Background: Dosing strategies of β-lactams and vancomycin should be optimized according
to pharmacokinetic/pharmacodynamic principles. However, there is no available data …