β-lactam precision dosing in critically ill children: Current state and knowledge gaps

S Tang Girdwood, K Pavia, K Paice… - Frontiers in …, 2022 - frontiersin.org
There has been emerging interest in implementing therapeutic drug monitoring and model-
informed precision dosing of β-lactam antibiotics in critically ill patients, including children …

Meropenem for the Pharmacological Treatment of Severe Infections in Critically Ill Pediatric Patients: Breakthrough Standard Treatment Strategies Based on PK/PD

X He, Y Liu, X Gong, L Wang… - Current Drug …, 2023 - ingentaconnect.com
Meropenem, as a carbapenem antibiotic, is commonly used in critically ill pediatric patients
with severe infection because of its broad antimicrobial spectrum, high penetration into …

[HTML][HTML] Therapeutic drug monitoring of meropenem and pharmacokinetic-pharmacodynamic target assessment in critically ill pediatric patients from a prospective …

P Maimongkol, W Yonwises, S Anugulruengkitt… - International Journal of …, 2022 - Elsevier
Objectives To compare the unbound plasma meropenem concentrations at mid-dosing
intervals (C mid, 50% fT), end-dosing intervals (C trough, 100% fT), and proportions of …

[HTML][HTML] Effects of voriconazole on population pharmacokinetics and optimization of the initial dose of tacrolimus in children with chronic granulomatous disease …

X Chen, D Wang, J Lan, G Wang, L Zhu… - Annals of …, 2021 - ncbi.nlm.nih.gov
Background This study aimed to explore the effects of voriconazole on population
pharmacokinetics and optimization of the initial dose of tacrolimus in children with chronic …

Meropenem Disposition in Neonatal and Pediatric Extracorporeal Membrane Oxygenation and Continuous Renal Replacement Therapy

P Pokorná, D Michaličková, D Tibboel, J Berner - Antibiotics, 2024 - mdpi.com
This study aimed to characterize the impact of extracorporeal membrane oxygenation
(ECMO) on the pharmacokinetics (PK) of meropenem in neonates and children and to …

Population PK/PD modelling of meropenem in preterm newborns based on therapeutic drug monitoring data

S Zyryanov, I Bondareva, O Butranova… - Frontiers in …, 2023 - frontiersin.org
Background: Preterm neonates rarely participate in clinical trials, this leads to lack of
adequate information on pharmacokinetics for most drugs in this population. Meropenem is …

The OBTAINS study: a nationwide cross-sectional survey on the implementation of extended or continuous infusion of β-lactams and vancomycin among neonatal …

P Zhou, Y Cheng, G Cao, Y Xing, S Zhai… - Frontiers in …, 2022 - frontiersin.org
Background: Dosing strategies of β-lactams and vancomycin should be optimized according
to pharmacokinetic/pharmacodynamic principles. However, there is no available data …

[HTML][HTML] Evaluation of pharmacokinetic pharmacodynamic target attainment of meropenem in pediatric patients

A Alsultan, MR Aldawsari, NK Alturaiq, SA Syed… - Pediatrics & …, 2024 - Elsevier
Background Meropenem is a widely used carbapenem for treating severe pediatric
infections. However, few studies have assessed its pharmacokinetics/pharmacodynamics …

การ ตรวจ ติดตาม ระดับ ยา meropenem และ การ ประเมิน ผล การ รักษา ทาง คลินิก ใน ผู้ ป่วย เด็ก วิกฤต

ไม้ มงคล, ภั ส ส รา - 2021 - digital.car.chula.ac.th
Abstract การ ติด เชื้อ แบคทีเรีย แก รม ลบ ดื้อยา หลาย ขนาน (multidrug-resistant Gram-negative
bacteria, MDR-GNB) ใน โรง พยาบาล ทำให้ ผู้ ป่วย วิกฤต มี อัตรา การ เสีย ชีวิต สูง ขึ้น นอกจาก นี้ …

[引用][C] Pengxiang Zhou1, 2, 3, 4, Yinchu Cheng3, 4, Guangna Cao5, Yan Xing5, Suodi Zhai3, 4, Xiaomei Tong5* and Kehu Yang1, 2

P Zhou, Y Cheng, G Cao, Y Xing, S Zhai - 2022 - europepmc.org
Background: Dosing strategies of β-lactams and vancomycin should be optimized according
to pharmacokinetic/pharmacodynamic principles. However, there is no available data …