Although exercise is associated with depression relief, the effects of aerobic exercise (AE)
interventions on clinically depressed adult patients have not been clearly supported. The …

Diagnostic triage is an essential guideline recommendation for low back pain (LBP), which
is the most frequent musculoskeletal condition that general practitioners encounter in …

Importance Opioid analgesics are commonly used for low back pain, however, to our
knowledge there has been no systematic evaluation of the effect of opioid dose and use of …

Key Clinical Points Herniated Lumbar Intervertebral Disk Herniated lumbar disks are the
leading cause of sciatica, but they also are detected on imaging (MRI or CT) in …

Background While it is now clear that paracetamol is ineffective for spinal pain, there is not
consensus on the efficacy of non-steroidal anti-inflammatory drugs (NSAIDs) for this …

Entrapment neuropathies such as carpal tunnel syndrome, radiculopathies, or radicular pain
are the most common peripheral neuropathies and also the most common cause for …

Objectives Evidence comparing the effectiveness of surgical and conservative treatment of
symptomatic lumbar disc herniation is controversial. We sought to compare short-term and …

Introduction: The first two alpha2delta ligands–gabapentin (GBP) and pregabalin (PGB)–
were initially synthesized as antiepileptics; however, they were later also found to be useful …

BACKGROUND: The use of anticonvulsants (eg, gabapentin, pregabalin) to treat low back
pain has increased substantially in recent years despite limited supporting evidence. We …

Background: Existing guidelines and systematic reviews provide inconsistent
recommendations on epidural corticosteroid injections for sciatica. Key limitations of existing …