How to turn up the heat on the cold immune microenvironment of metastatic prostate cancer
Background Advanced prostate cancer remains one of the most common and deadly
cancers, despite advances in treatment options. Immunotherapy has provided little benefit to …
cancers, despite advances in treatment options. Immunotherapy has provided little benefit to …
Interactions between the immune and nervous systems in pain
K Ren, R Dubner - Nature medicine, 2010 - nature.com
Immune cells and glia interact with neurons to alter pain sensitivity and to mediate the
transition from acute to chronic pain. In response to injury, resident immune cells are …
transition from acute to chronic pain. In response to injury, resident immune cells are …
Astrocytes monitor cerebral perfusion and control systemic circulation to maintain brain blood flow
Astrocytes provide neurons with essential metabolic and structural support, modulate
neuronal circuit activity and may also function as versatile surveyors of brain milieu, tuned to …
neuronal circuit activity and may also function as versatile surveyors of brain milieu, tuned to …
Central mechanisms of pathological pain
R Kuner - Nature medicine, 2010 - nature.com
Chronic pain is a major challenge to clinical practice and basic science. The peripheral and
central neural networks that mediate nociception show extensive plasticity in pathological …
central neural networks that mediate nociception show extensive plasticity in pathological …
Cellular function and molecular structure of ecto-nucleotidases
Ecto-nucleotidases play a pivotal role in purinergic signal transmission. They hydrolyze
extracellular nucleotides and thus can control their availability at purinergic P2 receptors …
extracellular nucleotides and thus can control their availability at purinergic P2 receptors …
Adenosine A1 receptors mediate local anti-nociceptive effects of acupuncture
N Goldman, M Chen, T Fujita, Q Xu, W Peng… - Nature …, 2010 - nature.com
Acupuncture is an invasive procedure commonly used to relieve pain. Acupuncture is
practiced worldwide, despite difficulties in reconciling its principles with evidence-based …
practiced worldwide, despite difficulties in reconciling its principles with evidence-based …
Enzymes involved in metabolism of extracellular nucleotides and nucleosides: functional implications and measurement of activities
GG Yegutkin - Critical reviews in biochemistry and molecular …, 2014 - Taylor & Francis
Extracellular nucleotides and nucleosides mediate diverse signaling effects in virtually all
organs and tissues. Most models of purinergic signaling depend on functional interactions …
organs and tissues. Most models of purinergic signaling depend on functional interactions …
Functional oxygen sensitivity of astrocytes
PR Angelova, V Kasymov, I Christie… - Journal of …, 2015 - Soc Neuroscience
In terrestrial mammals, the oxygen storage capacity of the CNS is limited, and neuronal
function is rapidly impaired if oxygen supply is interrupted even for a short period of time …
function is rapidly impaired if oxygen supply is interrupted even for a short period of time …
Adenosine receptor targets for pain
J Sawynok - Neuroscience, 2016 - Elsevier
The main focus for the development of adenosine targets as analgesics to date has been A
1 Rs due to its antinociceptive profile in various preclinical pain models. The usefulness of …
1 Rs due to its antinociceptive profile in various preclinical pain models. The usefulness of …
Neuropathic pain promotes adaptive changes in gene expression in brain networks involved in stress and depression
G Descalzi, V Mitsi, I Purushothaman, S Gaspari… - Science …, 2017 - science.org
Neuropathic pain is a complex chronic condition characterized by various sensory,
cognitive, and affective symptoms. A large percentage of patients with neuropathic pain are …
cognitive, and affective symptoms. A large percentage of patients with neuropathic pain are …