Chalcone derivatives and their antibacterial activities: Current development
M Xu, P Wu, F Shen, J Ji, KP Rakesh - Bioorganic Chemistry, 2019 - Elsevier
The increase in antibiotic resistance due to various factors has encouraged the look for
novel compounds which are active against multidrug-resistant pathogens. In this framework …
novel compounds which are active against multidrug-resistant pathogens. In this framework …
Ferrocene-containing hybrids as potential anticancer agents: Current developments, mechanisms of action and structure-activity relationships
Cancer is one of the most fatal threatens to human health throughout the world. The major
challenges in the control and eradication of cancers are the continuous emergency of drug …
challenges in the control and eradication of cancers are the continuous emergency of drug …
In vitro enzymatic evaluation of some pyrazolo[1,5‐a]pyrimidine derivatives: Design, synthesis, antioxidant, anti‐diabetic, anti‐Alzheimer, and anti‐arthritic activities …
AS Hassan, NM Morsy… - Drug Development …, 2023 - Wiley Online Library
The strategy of utilizing nitrogen compounds in various biological applications has recently
emerged as a powerful approach to exploring novel classes of therapeutics to face the …
emerged as a powerful approach to exploring novel classes of therapeutics to face the …
Design, synthesis, anticancer evaluation, enzymatic assays, and a molecular modeling study of novel pyrazole–indole hybrids
AS Hassan, GO Moustafa, HM Awad, ES Nossier… - ACS …, 2021 - ACS Publications
The molecular hybridization concept has recently emerged as a powerful approach in drug
discovery. A series of novel indole derivatives linked to the pyrazole moiety were designed …
discovery. A series of novel indole derivatives linked to the pyrazole moiety were designed …
Schiff bases: Interesting scaffolds with promising antitumoral properties
D Iacopetta, J Ceramella, A Catalano, C Saturnino… - Applied Sciences, 2021 - mdpi.com
Schiff bases, named after Hugo Schiff, are highly reactive organic compounds broadly used
as pigments and dyes, catalysts, intermediates in organic synthesis, and polymer stabilizers …
as pigments and dyes, catalysts, intermediates in organic synthesis, and polymer stabilizers …
Antibacterial evaluation, in silico characters and molecular docking of Schiff bases derived from 5-aminopyrazoles
A series of Schiff bases 14–25 were designed and synthesized for evaluation of their
antibacterial properties against multi-drug resistant bacteria (MDRB). The antibacterial …
antibacterial properties against multi-drug resistant bacteria (MDRB). The antibacterial …
Synthesis, molecular docking, and in silico ADME prediction of some fused pyrazolo[1,5-a]pyrimidine and pyrazole derivatives as potential antimicrobial agents
Abstract Twenty compounds of pyrazolo [1, 5-a] pyrimidines 14a–j and pyrazole derivatives
as Schiff bases 16a–j have been synthesized by the reaction of 5-amino-pyrazole …
as Schiff bases 16a–j have been synthesized by the reaction of 5-amino-pyrazole …
Discovery of new Schiff bases tethered pyrazole moiety: Design, synthesis, biological evaluation, and molecular docking study as dual targeting DHFR/DNA gyrase …
A series of Bis-pyrazole Schiff bases (6a–d and 7a–d) and mono-pyrazole Schiff bases (8a–
d and 9a–d) were designed and synthesized through the reaction of 5-aminopyrazoles 1a–d …
d and 9a–d) were designed and synthesized through the reaction of 5-aminopyrazoles 1a–d …
Synthesis and antitumor activity of some new pyrazolo [1, 5-a] pyrimidines
Abstract New series of pyrazolo [1, 5-a] pyrimidine derivatives 7a–i, 11a–c and Schiff bases
13a–c were synthesized and screened for their in vitro antitumor activity against three …
13a–c were synthesized and screened for their in vitro antitumor activity against three …
Overview on synthesis, reactions, applications, and biological activities of Schiff bases
SS Mukhtar, AS Hassan, NM Morsy… - Egyptian Journal of …, 2021 - ejchem.journals.ekb.eg
Schiff bases exhibited various pharmacological and biological activities such as
antibacterial, cytotoxic effects, antifungal, and antimalarial. Schiff bases were used for …
antibacterial, cytotoxic effects, antifungal, and antimalarial. Schiff bases were used for …