Polypharmacology is a concept where a molecule can interact with two or more targets
simultaneously. It offers many advantages as compared to the conventional single-targeting …

Through the representation of small molecule structures as numerical descriptors and the
exploitation of the similarity principle, chemoinformatics has made paramount contributions …

We offer a path-centric theory of emerging technology and organizing that addresses a basic
question. When does emerging technology lead to transformative change? A path-centric …

Drug development is expensive, time-consuming, and has a high failure rate. In recent
years, artificial intelligence (AI) has emerged as a transformative tool in drug discovery …

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Frontiers in Pharmacology About us About us Who we are Mission Values History …

Identification of potential targets for known bioactive compounds and novel synthetic
analogs is of considerable significance. In silico target fishing (TF) has become an …

The reductionist concept, based on the ligand–receptor interaction, is not a suitable model
for adaptogens, and herbal preparations affect multiple physiological functions, revealing …

Polypharmacology is an emerging strategy of design, synthesis, and clinical implementation
of pharmaceutical agents that act on multiple targets simultaneously. It should not be mixed …

Alzheimer's disease (AD) is a complex and widespread condition, still not fully understood
and with no cure yet. Amyloid beta (Aβ) peptide is suspected to be a major cause of AD, and …

Background Prospects for the drug treatment of acute lung injury (ALI) is unpromising.
Managing inflammation can prevent ALI from progressing and minimize further deterioration …