For the past century, insulin injections have saved millions of lives, but glycemic instability is
still a persistent challenge for people with diabetes, leading to tremendous morbidity and …

Abstract Primary Biliary Cholangitis (PBC) is an uncommon, chronic, cholangiopathy of
autoimmune origin and unknown etiology characterized by positive anti-mitochondrial …

The effective suppression of adaptive immune responses is essential for the success of
allogeneic cell therapies. In islet transplantation for Type 1 Diabetes, pre-existing …

Type 1 diabetes mellitus (T1DM) is an autoimmune condition that results in the destruction of
insulin-secreting β cells of the islets of Langerhans. Allogeneic islet transplantation could be …

Profiling of circulating immune cells provides valuable insight to the pathophysiology of
acute rejection in organ transplantation. Herein we characterized the peripheral blood …

Pancreas and islet transplantation (PTx) are currently the only curative treatment options for
type 1 diabetes. CD4+ and CD8+ T cells play a pivotal role in graft function, rejection, and …

Memory T lymphocytes constitute a significant problem in tissue and organ transplantation
due their contribution to early rejection and their relative resistance to tolerance-promoting …

The success of human induced pluripotent stem cell (hiPSC)-based therapy critically
depends on understanding and controlling the immunological effects of the hiPSC-derived …

Since the discovery of mesenchymal stromal cells (MSCs) ability to repair craniofacial
defects and immunomodulatory properties, they became focus of research due to their …

Abstract Primary Biliary Cholangitis (PBC) is an uncommon, chronic, cholangiopathy of
autoimmune origin and unknown etiology characterized by positive anti-mitochondrial …