Alzheimer disease (AD) is characterized by progressive cognitive decline in older
individuals accompanied by the presence of two pathological protein aggregates—amyloid …

The amyloid-β oligomer (AβO) hypothesis was introduced in 1998. It proposed that the brain
damage leading to Alzheimer's disease (AD) was instigated by soluble, ligand-like AβOs …

Tau aggregation in neurofibrillary tangles (NFTs) is closely associated with
neurodegeneration and cognitive decline in Alzheimer's disease (AD). However, the …

Cellular perturbations underlying Alzheimer's disease (AD) are primarily studied in human
postmortem samples and model organisms. Here, we generated a single-nucleus atlas from …

The sodium and potassium gradients across the plasma membrane are used by animal cells
for numerous processes, and the range of demands requires that the responsible ion pump …

Alzheimer disease (AD) represents an oncoming epidemic that without an effective
treatment promises to exact extraordinary human and financial burdens. Studies of …

It is widely accepted that β-amyloid oligomers (Aβos) play a key role in the progression of
Alzheimer's disease (AD) by inducing neuron damage and cognitive impairment, but Aβos …

Several different receptor proteins have been identified that bind monomeric, oligomeric, or
fibrillar forms of amyloid-β (Aβ)." Good" receptors internalize Aβ or promote its transcytosis …

Beta amyloid, Aβ 1–42, originally named as Amyloid A4 protein, is one of the most
investigated peptides in neuroscience and has attracted substantial interest since its …

The structural polymorphism and the physiological and pathophysiological roles of two
important proteins, β-amyloid (Aβ) and tau, that play a key role in Alzheimer's disease (AD) …