The stem cell-based therapy has emerged as a promising therapeutic strategy for treating
cardiovascular ischemic diseases (CVIDs), such as myocardial infarction (MI). However …

The stem cell-based therapy has emerged as the promising therapeutic strategies for
cardiovascular diseases (CVDs). Recently, increasing evidence suggest stem cell-derived …

Generation of homogeneous populations of subtype-specific cardiomyocytes (CMs) derived
from human induced pluripotent stem cells (iPSCs) and their comprehensive phenotyping is …

Background Short QT syndrome (SQTS), a disorder associated with characteristic ECG QT‐
segment abbreviation, predisposes affected patients to sudden cardiac death. Despite some …

Human induced pluripotent stem cell derived cardiomyocytes (hiPSC-CMs) are widely used
in studying basic mechanisms of cardiac arrhythmias that are caused by ion …

Abstract Background: The National Cardiovascular Data Registry (NCDR) launched the
IMPACT (Improving Pediatric and Adult Congenital Treatment) Registry in 2010. By 2013, its …

Rationale Lysosomal associated membrane protein type-2 (LAMP-2) is a highly conserved,
ubiquitous protein that is critical for autophagic flux. Loss of function mutations in the LAMP …

A rapidly increasing number of papers describing novel iPSC models for cardiac diseases
are being published. To be able to understand the disease mechanisms in more detail, we …

Since its initial description by Jervell and Lange‐Nielsen in 1957, the congenital long QT
syndrome (LQTS) has been the most investigated cardiac ion channelopathy. A prolonged …

Atrial fibrillation (AF) is the most common cardiac arrhythmia in clinical practice with a large
socioeconomic impact due to its associated morbidity, mortality, reduction in quality of life …