Chalcone derivatives: role in anticancer therapy
Y Ouyang, J Li, X Chen, X Fu, S Sun, Q Wu - Biomolecules, 2021 - mdpi.com
Chalcones (1, 3-diaryl-2-propen-1-ones) are precursors for flavonoids and isoflavonoids,
which are common simple chemical scaffolds found in many naturally occurring compounds …
which are common simple chemical scaffolds found in many naturally occurring compounds …
Chalcone: a privileged structure in medicinal chemistry
Privileged structures have been widely used as an effective template in medicinal chemistry
for drug discovery. Chalcone is a common simple scaffold found in many naturally occurring …
for drug discovery. Chalcone is a common simple scaffold found in many naturally occurring …
Artemisinin as an anticancer drug: Recent advances in target profiling and mechanisms of action
Artemisinin and its derivatives (collectively termed as artemisinins) are among the most
important and effective antimalarial drugs, with proven safety and efficacy in clinical use …
important and effective antimalarial drugs, with proven safety and efficacy in clinical use …
Chalcone hybrids as potential anticancer agents: Current development, mechanism of action, and structure‐activity relationship
F Gao, G Huang, J Xiao - Medicinal research reviews, 2020 - Wiley Online Library
The continuous emergency of drug‐resistant cancers and the low specificity of anticancer
agents have been the major challenges in the control and treatment of cancer, making an …
agents have been the major challenges in the control and treatment of cancer, making an …
Artemisinin-derived hybrids and their anticancer activity
F Gao, Z Sun, F Kong, J Xiao - European journal of medicinal chemistry, 2020 - Elsevier
The emergence of drug-resistance and the low specificity of anticancer agents are the major
challenges in the treatment of cancer and can result in many side effects, creating an urgent …
challenges in the treatment of cancer and can result in many side effects, creating an urgent …
Artemisinin-type drugs for the treatment of hematological malignancies
RI Mancuso, MA Foglio, ST Olalla Saad - Cancer chemotherapy and …, 2021 - Springer
Qinghaosu, known as artemisinin (ARS), has been for over two millennia, one of the most
common herbs prescribed in traditional Chinese medicine (TCM). ARS was developed as …
common herbs prescribed in traditional Chinese medicine (TCM). ARS was developed as …
Sesquiterpene lactones as promising candidates for cancer therapy: Focus on pancreatic cancer
LC Laurella, NT Mirakian, MN Garcia, DH Grasso… - Molecules, 2022 - mdpi.com
Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive disease which confers to
patients a poor prognosis at short term. PDAC is the fourth leading cause of death among …
patients a poor prognosis at short term. PDAC is the fourth leading cause of death among …
Antitumor research on artemisinin and its bioactive derivatives
Y Zhang, G Xu, S Zhang, D Wang… - Natural products and …, 2018 - Springer
Cancer is the leading cause of human death which seriously threatens human life. The
antimalarial drug artemisinin and its derivatives have been discovered with considerable …
antimalarial drug artemisinin and its derivatives have been discovered with considerable …
More insights into the pharmacological effects of artemisinin
A Zyad, M Tilaoui, A Jaafari, MA Oukerrou… - Phytotherapy …, 2018 - Wiley Online Library
Artemisinin is one of the most widely prescribed drugs against malaria and has recently
received increased attention because of its other potential biological effects. The aim of this …
received increased attention because of its other potential biological effects. The aim of this …
Molecular hybridization as a strategy for developing artemisinin-derived anticancer candidates
E Marchesi, D Perrone, ML Navacchia - Pharmaceutics, 2023 - mdpi.com
Artemisinin is a natural compound extracted from Artemisia species belonging to the
Asteraceae family. Currently, artemisinin and its derivatives are considered among the most …
Asteraceae family. Currently, artemisinin and its derivatives are considered among the most …