Omega-3 polyunsaturated fatty acids (PUFAs) include α-linolenic acid (ALA; 18: 3 ω-3),
stearidonic acid (SDA; 18: 4 ω-3), eicosapentaenoic acid (EPA; 20: 5 ω-3) …

We conducted this meta-analysis of double-blind randomized placebo-controlled trials to
estimate the efficacy of omega-3 polyunsaturated fatty acids (PUFAs), especially …

Objective: There is burgeoning interest in augmentation strategies for improving inadequate
response to antidepressants. The adjunctive use of standardized pharmaceutical-grade …

Abstract Recently, omega-3 long-chain polyunsaturated fatty acids (n-3 LC-PUFAs) have
gained substantial interest due to their specific structure and biological functions. Humans …

Background Despite omega-3 polyunsaturated fatty acids (PUFA) supplementation in
depressed patients have been suggested to improve depressive symptomatology, previous …

Omega-3 polyunsaturated fatty acid (PUFA) supplementation has been proposed as
(adjuvant) treatment for major depressive disorder (MDD). In the present meta-analysis, we …

Major depressive disorder (MDD) is a complex mental illness with unmet therapeutic needs.
The antidepressant effects of ω–3 polyunsaturated fatty acids (n–3 PUFAs) have been …

Background Major depressive disorder (MDD) is highly debilitating, difficult to treat, has a
high rate of recurrence, and negatively impacts the individual and society as a whole. One …

BackgroundTrials evaluating efficacy of omega-3 highly unsaturated fatty acids (HUFAs) in
major depressive disorder report discrepant findings. AimsTo establish the reasons …

Microglia M1 phenotype causes HPA axis hyperactivity, neurotransmitter dysfunction, and
production of proinflammatory mediators and oxidants, which may contribute to the etiology …