Abstract Alzheimer's disease (AD), as the fourth leading cause of death among the elderly
worldwide, has brought enormous challenge to the society. Due to its extremely complex …

Acetylcholinesterase is a member of the α/β hydrolase protein super family, with a significant
role in acetylcholine-mediated neurotransmission. Research in the modulators of AChEs …

Alzheimer's disease (AD) is a progressive neurodegenerative disorder of the central
nervous system (CNS) which is the most common cause of dementia in the elderly. It is …

Butyrylcholinesterase (BChE) is a promising target for the treatment of later stage cognitive
decline in Alzheimer's disease. A set of pseudo-irreversible BChE inhibitors with high …

Acetylcholinesterase (AChE) is one of the most important drug targets for Alzheimer's
disease (AD) treatment. In this work, a machine learning model was trained to rapidly and …

Fe-catalyzed direct dehydrogenative C (3)-functionalization of tertiary arylamines was
developed via activation of the sp3 C (3)–H bond. The reaction is applicable to both cyclic …

Hydropyrrolo [2, 3-b] indole is a privileged indoline motif, while its analogue, hydropyrrolo [3,
2-b] indole, has been much less explored. Herein, we developed a cascade reaction of …

A systematic virtual screening (VS) experiment, consisting of the development of 3D-
pharmacophore, screening of virtual library, synthesis, and pharmacology, is reported. The …

Controlled inhibition of brain acetyl-and butyrylcholinesterases (AChE and BChE,
respectively) and of monoamine oxidase-B (MAO-B) may slow neurodegeneration in …

N-oxides play a pivotal role in natural products and emerging drug design, while also
serving as valuable ligand scaffolds in organometallic chemistry. Among heteroatom …