While antimicrobial resistance (AMR) is seen in both Neisseria gonorrhoeae and Neisseria
meningitidis, the former has become resistant to commonly available over-the-counter …

Highlights•Virulence enzymes are novel targets for development of antimicrobials.•
Screening and rational design have identified inhibitors of DSB and Mip …

Background The causative agent of melioidosis is the Gram-negative bacterium
Burkholderia pseudomallei. Clinical presentations of melioidosis are notably diverse, with …

Antibiotic activity is limited by the physical construction of the Gram-negative cell envelope.
Species of the Burkholderia cepacia complex (Bcc) are known as intrinsically multidrug …

Burkholderia pseudomallei is a soil-dwelling bacterium endemic to Southeast Asia and
northern Australia that causes the disease, melioidosis. Although the global genomic …

Abstract The invasive Burkholderia species, Burkholderia pseudomallei and Burkholderia
mallei, cause a remarkably wide range of disease outcomes, varying from subacute …

The presence of suitable cavities or pockets on protein structures is a general criterion for a
therapeutic target protein to be classified as 'druggable'. Many disease-related proteins that …

The disulfide bond (DSB) forming system and in particular DsbA, is a key bacterial oxidative
folding catalyst. Due to its role in promoting the correct assembly of a wide range of …

Identification of bacterial virulence factors is critical for understanding disease pathogenesis,
drug discovery and vaccine development. In this study we used two approaches to predict …

Chlamydia trachomatis is an obligate intracellular bacterium with a distinctive biphasic
developmental cycle that alternates between two distinct cell types; the extracellular …