A bstract This review summarizes the recent research development on vertebrate sialidase
biology. Sialic acid-containing compounds play important roles in many physiological …

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OBJECTIVE: GATA-1 and GATA-2 transcription factors are required for effective
hematopoiesis. These regulatory proteins present overlapping yet distinct patterns of …

Multidrug resistance (MDR) in cancer arises from cross-resistance to structurally-and
functionally-divergent chemotherapeutic drugs. In particular, MDR is characterized by …

Lysosomal neuraminidase-1 (NEU1) forms a multienzyme complex with β-galactosidase
and protective protein/cathepsin A (PPCA). Because of its association with PPCA, which acts …

Embryonic stem cells are characterized by their differentiation to all cell types during
embryogenesis. In adult life, different tissues also have somatic stem cells, called adult stem …

Oxidative glutamate toxicity has been implicated in the pathology of neuronal cell death.
However, the underlying mechanism responsible for this is not fully understood …

Abnormal carbohydrates expressed on tumor cells, which are termed tumor-associated
carbohydrate antigens (TACAs), are potential targets for the development of cancer …

FAXDC2 (fatty acid hydroxylase domain containing 2) is a member of the fatty acid
hydroxylase superfamily. Given the important role of fatty acids in megakaryocytes, we have …

Cholera and Shiga toxin bind to the cell surface via glycolipid receptors GM1 and Gb3,
respectively. Surprisingly, the majority of Vero cells from a non-synchronized population …