Background This review is the third update of the Cochrane review" Selenium for preventing
cancer". Selenium is a naturally occurring element with both nutritional and toxicological …

Cadherins are mediators of cell–cell adhesion in epithelial tissues. E-cadherin is a known
tumour suppressor and plays a central role in suppressing the invasive phenotype of cancer …

Urothelial bladder cancers (UBCs) have heterogeneous clinical characteristics that are
mirrored in their diverse genomic profiles. Genomic profiling of UBCs has the potential to …

High-grade non-muscle invasive bladder cancer (HG-NMIBC) is a clinically unpredictable
disease with greater risks of recurrence and progression relative to their low-intermediate …

Background Highly sensitive and specific urine-based tests to detect either primary or
recurrent bladder cancer have proved elusive to date. Our ever increasing knowledge of the …

Background Urothelial bladder cancer is most frequently diagnosed at the non-muscle-
invasive stage (NMIBC). However, recurrences and interventions for intermediate and high …

INTRODUCTION Bladder cancer recurrence occurs via four mechanisms-incomplete
resection, tumour cell re-implantation, growth of microscopic tumours, and new tumour …

Objectives To develop a focused panel of somatic mutations (SM s) present in the majority of
urothelial bladder cancers (UBC s), to investigate the diagnostic and prognostic utility of this …

Background: TERT promotor mutations are present in> 75% of bladder tumours; these
mutations are also detectable in urine. Previous studies have used urinary pellet DNA, and …

Purpose: Virotherapies are maturing in the clinical setting. Adenoviruses (Ad) are excellent
vectors for the manipulability and tolerance of transgenes. Poor tumor selectivity, off-target …