The impaired insulin secretion and increased insulin resistance (or decreased insulin
sensitivity) play a major role in the pathogenesis of all types of diabetes mellitus (DM). It is …

This review takes an inclusive approach to microvascular dysfunction in diabetes mellitus
and cardiometabolic disease. In virtually every organ, dynamic interactions between the …

Insulin is the paramount anabolic hormone, promoting carbon energy deposition in the
body. Its synthesis, quality control, delivery, and action are exquisitely regulated by highly …

Both type 1 and type 2 diabetes adversely affect the microvasculature in multiple organs.
Our understanding of the genesis of this injury and of potential interventions to prevent, limit …

Insulin resistance contributes to the pathophysiology of diabetes and is a hallmark of
obesity, metabolic syndrome, and many cardiovascular diseases. Therefore, quantifying …

Insulin has important vascular actions to stimulate production of nitric oxide from
endothelium. This leads to capillary recruitment, vasodilation, increased blood flow, and …

Type 2 diabetes continues to negatively impact the health of millions. The inability to
respond to insulin to clear blood glucose (insulin resistance) is a key pathogenic driver of …

Chronic obstructive pulmonary disease (COPD) is a major incurable global health burden
and is currently the 4th largest cause of death in the world. Importantly, much of the disease …

Endothelial dysfunction is defined as impairment of the balance between endothelium‐
dependent vasodilation and constriction. Despite evidence of uric acid‐induced endothelial …

Evidence suggests that insulin delivery to skeletal muscle interstitium is the rate-limiting step
in insulin-stimulated muscle glucose uptake and that this process is impaired by insulin …