Background Ferroptosis, as a new form of cell death, is different from other cell deaths such
as autophagy or senescence. Ferroptosis involves in the pathophysiological progress of …

Huntington's disease is an inherited neurodegenerative disease described 150 years ago
by George Huntington. The genetic defect was identified in 1993 to be an expanded CAG …

Huntington's disease (HD) is a devastating monogenic neurodegenerative disease
characterized by early, selective pathology in the basal ganglia despite the ubiquitous …

Tandem repeat diseases include the neurodegenerative disorders known as polyglutamine
(polyQ) diseases, caused by CAG repeat expansions in the coding regions of the respective …

The complexity of affected brain regions and cell types is a challenge for Huntington's
disease (HD) treatment. Here we use single nucleus RNA sequencing to investigate …

Glial cells play critical roles in the normal development and function of neural circuits, but in
many neurodegenerative diseases, they become dysregulated and may contribute to the …

Huntington's disease (HD) is characterized by defective oligodendroglial differentiation and
white matter disease. Here, we investigate the role of oligodendrocyte progenitor cell (OPC) …

Spinocerebellar ataxia Type 3 (SCA3), the most common dominantly inherited ataxia, is a
polyglutamine neurodegenerative disease for which there is no disease-modifying therapy …

Myelination depends on the maintenance of oligodendrocytes that arise from
oligodendrocyte precursor cells (OPCs). We show that OPC-specific proliferation …

Cholesterol is an important metabolite and membrane component and is enriched in the
brain owing to its role in neuronal maturation and function. In the adult brain, cholesterol is …