Meiotic recombination is a fundamental feature of sexually reproducing species. It is often
required for proper chromosome segregation and plays important role in adaptation and the …

The spatial folding of chromosomes inside the nucleus has regulatory effects on gene
expression, yet the impact of genome reshuffling on this organization remains unclear. Here …

In many species, meiotic recombination events tend to occur in narrow intervals of the
genome, known as hotspots. In humans and mice, double strand break (DSB) hotspot …

Meiotic recombination starts with the formation of DNA double-strand breaks (DSBs) at
specific genomic locations that correspond to PRDM9-binding sites. The molecular steps …

The classical definition posits hybrid sterility as a phenomenon when two parental taxa each
of which is fertile produce a hybrid that is sterile. The first hybrid sterility gene in vertebrates …

Meiotic recombination is an important evolutionary force and an essential meiotic process. In
many species, recombination events concentrate into hotspots defined by the site-specific …

Molecular dissection of meiotic recombination in mammals, combined with population-
genetic and comparative studies, have revealed a complex evolutionary dynamic …

Hybrid sterility is a reproductive isolation barrier between diverging taxa securing the early
steps of speciation. Hybrid sterility is ubiquitous in the animal and plant kingdoms, but its …

Chromosomal fusions represent one of the most common types of chromosomal
rearrangements found in nature. Yet, their role in shaping the genomic landscape of …

PRDM9-mediated reproductive isolation was first described in the progeny of Mus musculus
musculus (MUS) PWD/Ph and Mus musculus domesticus (DOM) C57BL/6J inbred strains …