Nucleoside analogues (NA) are essential components of AML induction therapy (cytosine
arabinoside), effective treatments of lymphoproliferative disorders (fludarabine, cladribine) …

The methylation of DNA is an epigenetic modification that can play an important role in the
control of gene expression in mammalian cells. The enzyme involved in this process is DNA …

Aza-2'-deoxycytidine (5-AZA-CdR, Decitabine) is a nucleoside analog and an active drug for
the therapy of acute leukemia. The incorporation of 5-AZA-CdR into DNA blocks DNA …

Deoxycytidine kinase (dCK) is essential for the phosphorylation of gemcitabine (2′, 2′-
difluorodeoxycytidine), a deoxycytidine analogue active against various solid tumors …

Purpose: The hematopoietic toxicity produced by the cytosine nucleoside analogs is a
critical problem that limits their effectiveness in cancer therapy. One strategy to prevent this …

Methylation-induced gene silencing represents a major obstacle to efficient transgene
expression in pluripotent cells and thereof derived tissues. As ubiquitous chromatin opening …

First-line chemotherapy treatment in acute-myeloid leukemia patients usually consists of a
combination of cytarabine (ara-C) and an anthracycline. These regimens induce complete …

The cytotoxic activity of cytarabine (ara‐C) in leukaemic blasts depends on activating
enzymes such as deoxycytidine kinase (dCK) and inactivating enzymes such as the 5 …

Gene transfer of the cytidine deaminase (CDD) cDNA has recently been shown to induce
cellular resistance to cytarabine (AraC) in vitro. To investigate the role for CDD in acute …

The genetic transfer of drug resistance to hematopoietic cells is an attractive approach to
overcoming myelosuppression caused by high-dose chemotherapy. Because …