Targeting the cerebrovascular system: next-generation biomarkers and treatment for mild traumatic brain injury

TL Baker, DV Agoston, RD Brady, B Major… - The …, 2022 - journals.sagepub.com
The diagnosis, prognosis, and treatment of mild traumatic brain injuries (mTBIs), such as
concussions, are significant unmet medical issues. The kinetic forces that occur in mTBI …

Prolonged elevation of serum neurofilament light after concussion in male Australian football players

SJ McDonald, WT O'Brien, GF Symons, Z Chen… - Biomarker …, 2021 - Springer
Background Biomarkers that can objectively guide the diagnosis of sports-related
concussion, and consequent return-to-play decisions, are urgently needed. In this study, we …

Serum protein biomarker findings reflective of oxidative stress and vascular abnormalities in male, but not female, collision sport athletes

BP Major, SJ McDonald, WT O'Brien… - Frontiers in …, 2020 - frontiersin.org
Studies have indicated that concussive and sub-concussive brain injuries that are frequent
during collision sports may lead to long-term neurological abnormalities, however there is a …

Elevated serum interleukin-1β levels in male, but not female, collision sport athletes with a concussion history

WT O'Brien, GF Symons, J Bain, BP Major… - Journal of …, 2021 - liebertpub.com
It is increasingly reported that a history of concussion may be associated with chronic
deleterious consequences. While the pathophysiology that contributes to these …

Decrease in plasma miR-27a and miR-221 after concussion in Australian football players

SR Shultz, CJ Taylor, R Aggio-Bruce… - Biomarker …, 2022 - journals.sagepub.com
Introduction: Sports-related concussion (SRC) is a common form of brain injury that lacks
reliable methods to guide clinical decisions. MicroRNAs (miRNAs) can influence biological …

White and gray matter abnormalities in Australian footballers with a history of sports-related concussion: an MRI study

B Major, GF Symons, B Sinclair, WT O'Brien… - Cerebral …, 2021 - academic.oup.com
Sports-related concussion (SRC) is a form of mild traumatic brain injury that has been linked
to long-term neurological abnormalities. Australian rules football is a collision sport with …

Sub-acute changes on MRI measures of cerebral blood flow and venous oxygen saturation in concussed Australian rules footballers

DK Wright, TJ O'Brien, SR Shultz - Sports Medicine-Open, 2022 - Springer
Background Sports-related concussion (SRC) is common in collision sport athletes. There is
growing evidence that repetitive SRC can have serious neurological consequences …

Shortened telomeres and serum protein biomarker abnormalities in collision sport athletes regardless of concussion history and sex

GF Symons, M Clough, WT O'Brien… - Journal of …, 2020 - journals.sagepub.com
Mild brain injuries are frequent in athletes engaging in collision sports and have been linked
to a range of long-term neurological abnormalities. There is a need to identify how these …

Age of First Exposure to Collision Sports Does Not Affect Patient Reported Outcomes in Women and Men Community Rugby Players.

KJ Hunzinger, JB Caccese, KM Costantini… - Medicine and science …, 2021 - europepmc.org
Purpose This study aimed to determine the relationship between age of first exposure (AFE)
to repetitive head impacts through contact/collision sports and patient-reported outcomes in …

Biomarkers of neurobiologic recovery in adults with sport-related concussion

WT O'Brien, G Spitz, B Xie, BP Major… - JAMA network …, 2024 - jamanetwork.com
Importance Sport-related concussion (SRC), a form of mild traumatic brain injury, is a
prevalent occurrence in collision sports. There are no well-established approaches for …