Mitochondrial Ca2+ Signaling in Health, Disease and Therapy
The divalent cation calcium (Ca2+) is considered one of the main second messengers
inside cells and acts as the most prominent signal in a plethora of biological processes. Its …
inside cells and acts as the most prominent signal in a plethora of biological processes. Its …
Intracellular calcium dysregulation by the Alzheimer's disease-linked protein presenilin 2
Alzheimer's disease (AD) is the most common form of dementia. Even though most AD
cases are sporadic, a small percentage is familial due to autosomal dominant mutations in …
cases are sporadic, a small percentage is familial due to autosomal dominant mutations in …
Reduced reticulum–mitochondria Ca2+ transfer is an early and reversible trigger of mitochondrial dysfunctions in diabetic cardiomyopathy
Type 2 diabetic cardiomyopathy features Ca 2+ signaling abnormalities, notably an altered
mitochondrial Ca 2+ handling. We here aimed to study if it might be due to a dysregulation of …
mitochondrial Ca 2+ handling. We here aimed to study if it might be due to a dysregulation of …
TOM70 sustains cell bioenergetics by promoting IP3R3-mediated ER to mitochondria Ca2+ transfer
The mitochondrial translocase of the outer membrane (TOM) is a protein complex that is
essential for the post-translational import of nuclear-encoded mitochondrial proteins. Among …
essential for the post-translational import of nuclear-encoded mitochondrial proteins. Among …
PSEN2 (presenilin 2) mutants linked to familial Alzheimer disease impair autophagy by altering Ca2+ homeostasis
ABSTRACT PSEN2 (presenilin 2) is one of the 3 proteins that, when mutated, causes early
onset familial Alzheimer disease (FAD) cases. In addition to its well-known role within the γ …
onset familial Alzheimer disease (FAD) cases. In addition to its well-known role within the γ …
Defective mitochondrial pyruvate flux affects cell bioenergetics in Alzheimer's disease-related models
Mitochondria are key organelles for brain health. Mitochondrial alterations have been
reported in several neurodegenerative disorders, including Alzheimer's disease (AD), and …
reported in several neurodegenerative disorders, including Alzheimer's disease (AD), and …
Luminal transport through intact endoplasmic reticulum limits the magnitude of localized Ca2+ signals
CC Crapart, ZC Scott, T Konno… - Proceedings of the …, 2024 - National Acad Sciences
The endoplasmic reticulum (ER) forms an interconnected network of tubules stretching
throughout the cell. Understanding how ER functionality relies on its structural organization …
throughout the cell. Understanding how ER functionality relies on its structural organization …
Maprotiline restores ER homeostasis and rescues neurodegeneration via Histamine Receptor H1 inhibition in retinal ganglion cells
When the protein or calcium homeostasis of the endoplasmic reticulum (ER) is adversely
altered, cells experience ER stress that leads to various diseases including …
altered, cells experience ER stress that leads to various diseases including …
[HTML][HTML] Familial Alzheimer's disease-linked presenilin mutants and intracellular Ca2+ handling: A single-organelle, FRET-based analysis
An imbalance in Ca 2+ homeostasis represents an early event in the pathogenesis of
Alzheimer's disease (AD). Presenilin-1 and-2 (PS1 and PS2) mutations, the major cause of …
Alzheimer's disease (AD). Presenilin-1 and-2 (PS1 and PS2) mutations, the major cause of …
Simultaneous imaging of ER and cytosolic Ca2+ dynamics reveals long-distance ER Ca2+ waves in plants
F Resentini, M Grenzi, D Ancora… - Plant …, 2021 - academic.oup.com
Abstract Calcium ions (Ca2+) play a key role in cell signaling across organisms. In plants, a
plethora of environmental and developmental stimuli induce specific Ca2+ increases in the …
plethora of environmental and developmental stimuli induce specific Ca2+ increases in the …