Global colistin use: a review of the emergence of resistant Enterobacterales and the impact on their genetic basis
U Binsker, A Käsbohrer… - FEMS Microbiology …, 2022 - academic.oup.com
The dramatic global rise of MDR and XDR Enterobacterales in human medicine forced
clinicians to the reintroduction of colistin as last-resort drug. Meanwhile, colistin is used in …
clinicians to the reintroduction of colistin as last-resort drug. Meanwhile, colistin is used in …
Polymyxins and bacterial membranes: a review of antibacterial activity and mechanisms of resistance
C Ayoub Moubareck - Membranes, 2020 - mdpi.com
Following their initial discovery in the 1940s, polymyxin antibiotics fell into disfavor due to
their potential clinical toxicity, especially nephrotoxicity. However, the dry antibiotic …
their potential clinical toxicity, especially nephrotoxicity. However, the dry antibiotic …
Antibiotic adjuvants: an alternative approach to overcome multi-drug resistant Gram-negative bacteria
Antibiotic resistance in Gram-negative pathogens has emerged and constituted a global
crisis, thereby novel antibiotics and other anti-infective strategies are urgently needed …
crisis, thereby novel antibiotics and other anti-infective strategies are urgently needed …
Emergence of colistin resistance in multidrug-resistant Klebsiella pneumoniae and Escherichia coli strains isolated from cancer patients
MM Zafer, HA El-Mahallawy, A Abdulhak… - Annals of clinical …, 2019 - Springer
Background Colistin resistance is mainly driven by alterations in the Gram-negative outer
membrane lipopolysaccharides and is caused, in most cases, by mutations in mgrB gene …
membrane lipopolysaccharides and is caused, in most cases, by mutations in mgrB gene …
[HTML][HTML] Unraveling antimicrobial resistance using metabolomics
M Kok, L Maton, M van der Peet, T Hankemeier… - Drug Discovery …, 2022 - Elsevier
The emergence of antimicrobial resistance (AMR) in bacterial pathogens represents a
global health threat. The metabolic state of bacteria is associated with a range of genetic …
global health threat. The metabolic state of bacteria is associated with a range of genetic …
Understanding the epidemiology of multi-drug resistant gram-negative bacilli in the Middle East using a one health approach
I Dandachi, A Chaddad, J Hanna, J Matta… - Frontiers in …, 2019 - frontiersin.org
In the last decade, extended-spectrum cephalosporin and carbapenem resistant Gram-
negative bacilli (GNB) have been extensively reported in the literature as being …
negative bacilli (GNB) have been extensively reported in the literature as being …
Emergence of colistin-resistant hypervirulent Klebsiella pneumoniae (CoR-HvKp) in China
X Liu, Y Wu, Y Zhu, P Jia, X Li, X Jia, W Yu… - Emerging Microbes & …, 2022 - Taylor & Francis
Colistin is regarded as a last-resort agent to combat infections caused by multidrug-resistant
(MDR) Gram-negative bacteria, especially carbapenem-resistant isolates. In recent years …
(MDR) Gram-negative bacteria, especially carbapenem-resistant isolates. In recent years …
Emerging Transcriptional and Genomic Mechanisms Mediating Carbapenem and Polymyxin Resistance in Enterobacteriaceae: a Systematic Review of Current …
The spread of carbapenem-and polymyxin-resistant Enterobacteriaceae poses a significant
threat to public health, challenging clinicians worldwide with limited therapeutic options. This …
threat to public health, challenging clinicians worldwide with limited therapeutic options. This …
High prevalence of mgrB-mediated colistin resistance among carbapenem-resistant Klebsiella pneumoniae is associated with biofilm formation, and can be …
The global prevalence of colistin-resistant Klebsiella pneumoniae (ColRkp) facilitated by
chromosomal and plasmid-mediated Ara4N or PEtN-remodeled LPS alterations has steadily …
chromosomal and plasmid-mediated Ara4N or PEtN-remodeled LPS alterations has steadily …
Stability and genetic insights of the co-existence of blaCTX-M-65, blaOXA-1, and mcr-1.1 harboring conjugative IncI2 plasmid isolated from a clinical extensively-drug resistant …
J Feng, H Wu, Y Zhuang, J Luo, Y Chen, Y Wu… - Frontiers in Public …, 2023 - frontiersin.org
Background Co-existence of colistin, β-lactam and carbapenem in multidrug-resistant
Enterobacteriaceae isolates poses a serious threat to public health. In this study, we …
Enterobacteriaceae isolates poses a serious threat to public health. In this study, we …