Interleukin-27 (IL-27) is a cytokine with strikingly diverse influences on the immune
response. Although it was initially linked with the development of Th1 responses, it is now …

Adipose tissue constitutes an extremely active endocrine organ with a network of signaling
pathways enabling the organism to adapt to a wide range of different metabolic challenges …

In recent years, many paradigms concerning central nervous system (CNS) immunology
have been challenged and shifted, including the discovery of CNS-draining lymphatic …

Here we describe a reporter mouse strain designed to map the fate of cells that have
activated interleukin 17A (IL-17A). We found that IL-17-producing helper T cells (TH17 cells) …

Osteopontin (OPN) is a matricellular protein that mediates diverse biological functions. OPN
is involved in normal physiological processes and is implicated in the pathogenesis of a …

Immune cells mediate critical inflammatory and neurodegenerative processes in the CNS in
individuals with multiple sclerosis (MS). In MS, activated microglia, border-associated …

Allergic inflammation triggered by exposure of an allergen frequently leads to the onset of
chronic inflammatory diseases such as atopic dermatitis (AD) and bronchial asthma. The …

Multiple sclerosis (MS) is characterized by autoimmune inflammation and subsequent
neurodegeneration. It is believed that early in the disease course, proinflammatory T cells …

The NLRP3 inflammasome is a multiprotein complex consisting of three kinds of proteins,
NLRP3, ASC, and pro-caspase-1, and plays a role in sensing pathogens and danger …

It has been more than 15 years since the identification of individual interleukin-27 (IL-27)
and IL-27 receptor components. The last decade has seen the description of the signaling …