Rapid progress in deciphering the biological mechanism of Alzheimer's disease (AD) has
arisen from the application of molecular and cell biology to this complex disorder of the …

Notch signaling regulates many aspects of metazoan development and tissue renewal.
Accordingly, the misregulation or loss of Notch signaling underlies a wide range of human …

Amyloid precursor protein (APP) is endoproteolytically processed by BACE1 and γ-
secretase to release amyloid peptides (Aβ40 and 42) that aggregate to form senile plaques …

In the field of cell signaling, the new millennium is tein, ATF6, is a type 2 membrane protein
with its NH2 witnessing a new conceptual convergence: the realizaterminus in the cytosol …

The salutary intersection of fundamental cell biology with the study of disease is well
illustrated by the emerging elucidation of neurodegenerative disorders. Novel mechanisms …

Development makes reiterative use of a surprisingly small set of essential molecular signals:
the Wingless (Wg/Wnt), Hedgehog (Hh), Transforming Growth Factor-(TGF-), Receptor …

Abstract γ-secretase-like proteolysis at site 3 (S3), within the transmembrane domain,
releases the Notch intracellular domain (NICD) and activates CSL-mediated Notch …

Presenilins are components of the γ-secretase protein complex that mediates
intramembranous cleavage of βAPP and Notch proteins. A C. elegans genetic screen …

Recent research has identified some key players involved in the proteolytic processing of
amyloid precursor protein (APP) to amyloid β-peptide, the principal component of the …

It is anticipated that γ-secretase inhibitors (γ-Sec-I) that modulate Notch processing will alter
differentiation in tissues whose architecture is governed by Notch signaling. To explore this …