Purinergic signalling: therapeutic developments
G Burnstock - Frontiers in pharmacology, 2017 - frontiersin.org
Purinergic signalling, ie, the role of nucleotides as extracellular signalling molecules, was
proposed in 1972. However, this concept was not well accepted until the early 1990's when …
proposed in 1972. However, this concept was not well accepted until the early 1990's when …
Carotid body chemoreceptors: physiology, pathology, and implications for health and disease
R Iturriaga, J Alcayaga, MW Chapleau… - Physiological …, 2021 - journals.physiology.org
The carotid body (CB) is the main peripheral chemoreceptor for arterial respiratory gases O2
and CO2 and pH, eliciting reflex ventilatory, cardiovascular, and humoral responses to …
and CO2 and pH, eliciting reflex ventilatory, cardiovascular, and humoral responses to …
Purinergic signaling in the cardiovascular system
G Burnstock - Circulation research, 2017 - Am Heart Assoc
There is nervous control of the heart by ATP as a cotransmitter in sympathetic,
parasympathetic, and sensory-motor nerves, as well as in intracardiac neurons. Centers in …
parasympathetic, and sensory-motor nerves, as well as in intracardiac neurons. Centers in …
Neuronal networks in hypertension: recent advances
PG Guyenet, RL Stornetta, GMPR Souza… - …, 2020 - Am Heart Assoc
Neurogenic hypertension is associated with excessive sympathetic nerve activity to the
kidneys and portions of the cardiovascular system. Here we examine the brain regions that …
kidneys and portions of the cardiovascular system. Here we examine the brain regions that …
GLP1R attenuates sympathetic response to high glucose via carotid body inhibition
Background: Aberrant sympathetic nerve activity exacerbates cardiovascular risk in
hypertension and diabetes, which are common comorbidities, yet clinically sympathetic …
hypertension and diabetes, which are common comorbidities, yet clinically sympathetic …
Identifying obstructive sleep apnoea patients responsive to supplemental oxygen therapy
A possible precision-medicine approach to treating obstructive sleep apnoea (OSA) involves
targeting ventilatory instability (elevated loop gain) using supplemental inspired oxygen in …
targeting ventilatory instability (elevated loop gain) using supplemental inspired oxygen in …
LAGOS-NE: a multi-scaled geospatial and temporal database of lake ecological context and water quality for thousands of US lakes
PA Soranno, LC Bacon, M Beauchene, KE Bednar… - …, 2017 - academic.oup.com
Understanding the factors that affect water quality and the ecological services provided by
freshwater ecosystems is an urgent global environmental issue. Predicting how water quality …
freshwater ecosystems is an urgent global environmental issue. Predicting how water quality …
The logic of carotid body connectivity to the brain
The carotid body has emerged as a therapeutic target for cardio-respiratory-metabolic
diseases. With the expansive functions of the chemoreflex, we sought mechanisms to …
diseases. With the expansive functions of the chemoreflex, we sought mechanisms to …
Physiology of the carotid body: from molecules to disease
P Ortega-Sáenz, J López-Barneo - Annual review of physiology, 2020 - annualreviews.org
The carotid body (CB) is an arterial chemoreceptor organ located in the carotid bifurcation
and has a well-recognized role in cardiorespiratory regulation. The CB contains …
and has a well-recognized role in cardiorespiratory regulation. The CB contains …
P2X3 receptor antagonism attenuates the progression of heart failure
Despite advances in the treatment of heart failure, prognosis is poor, mortality high and there
remains no cure. Heart failure is associated with reduced cardiac pump function, autonomic …
remains no cure. Heart failure is associated with reduced cardiac pump function, autonomic …