Purinergic signalling, ie, the role of nucleotides as extracellular signalling molecules, was
proposed in 1972. However, this concept was not well accepted until the early 1990's when …

The carotid body (CB) is the main peripheral chemoreceptor for arterial respiratory gases O2
and CO2 and pH, eliciting reflex ventilatory, cardiovascular, and humoral responses to …

There is nervous control of the heart by ATP as a cotransmitter in sympathetic,
parasympathetic, and sensory-motor nerves, as well as in intracardiac neurons. Centers in …

Neurogenic hypertension is associated with excessive sympathetic nerve activity to the
kidneys and portions of the cardiovascular system. Here we examine the brain regions that …

Background: Aberrant sympathetic nerve activity exacerbates cardiovascular risk in
hypertension and diabetes, which are common comorbidities, yet clinically sympathetic …

A possible precision-medicine approach to treating obstructive sleep apnoea (OSA) involves
targeting ventilatory instability (elevated loop gain) using supplemental inspired oxygen in …

Understanding the factors that affect water quality and the ecological services provided by
freshwater ecosystems is an urgent global environmental issue. Predicting how water quality …

The carotid body has emerged as a therapeutic target for cardio-respiratory-metabolic
diseases. With the expansive functions of the chemoreflex, we sought mechanisms to …

The carotid body (CB) is an arterial chemoreceptor organ located in the carotid bifurcation
and has a well-recognized role in cardiorespiratory regulation. The CB contains …

Despite advances in the treatment of heart failure, prognosis is poor, mortality high and there
remains no cure. Heart failure is associated with reduced cardiac pump function, autonomic …