This paper provides a critical review of several possible mechanisms at different levels of
analysis underlying the effects and therapeutic potential of psychedelics. At the (1) …

Background Ketamine appears to have a therapeutic role in certain mental disorders, most
notably depression. However, the comparative performance of different formulations of …

Importance Major depressive disorder (MDD) is a substantial public health burden, but
current treatments have limited effectiveness and adherence. Recent evidence suggests that …

In recent years, the NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines) for
Adult Cancer Pain have undergone substantial revisions focusing on the appropriate and …

Background Sub-anaesthetic administration of ketamine is an emerging practice in patients
presenting treatment resistant depression (TRD), however several outstanding questions …

Background: The Canadian Network for Mood and Anxiety Treatments (CANMAT)
conducted a revision of the 2009 guidelines by updating the evidence and …

There are few medications with demonstrated efficacy for the treatment of posttraumatic
stress disorder (PTSD). Treatment guidelines have unequivocally designated psychotherapy …

Suicide is a complex public health problem of global importance. Suicidal behaviour differs
between sexes, age groups, geographic regions, and sociopolitical settings, and variably …

Depression is the third leading cause of disability in the world. Depressive symptoms may
be reduced within several weeks after the start of conventional antidepressants, but …

Background Ketamine is established as a rapid and effective treatment in adults with
treatment-resistant depression (TRD). The availability of different formulations and routes of …