This Review explores the class of plant-derived macrocyclic peptides called cyclotides. We
include an account of their discovery, characterization, and distribution in the plant kingdom …

Demand for food production has increased due to population growth. The negative
environmental impact of animal agriculture necessitates the search for alternatives to animal …

Cyclotides are plant-derived cyclic peptides that have a head-to-tail cyclic backbone and
three conserved disulphide bonds that form a cyclic cystine knot motif. They occur in plants …

The multiple functions of peptides released from proteins have immense potential in food
and health. In the past few decades, research interest in bioactive peptides of plant origin …

Cyclotides are globular microproteins with a unique head‐to‐tail cyclized backbone,
stabilized by three disulfide bonds forming a cystine knot. This unique circular backbone …

Currently, there is a growing preference for eco-friendly bioinsecticides over chemical
insecticides due to their safety. Plant extracts have emerged as a promising solution for this …

The cyclic peptides, cyclotides, are identified mostly with 29–31-aa (amino acid residues)
but rarely with≥ 34-aa in plants. Viola philippica is a well-known medicinal plant but a rare …

Cyclotides are fascinating microproteins (≈ 30–40 residues long) with a unique head-to-tail
cyclized backbone, stabilized by three disulfide bonds forming a cystine knot. This unique …

Cyclotides are an emerging class of disulfide-rich plant cyclic peptides, believed to be
present in plants for defence purposes. Their exceptional thermal, chemical and enzymatic …

Abstract Objectives The genus Viola belongs to the family Violaceae, and the plants from
this genus are essential folk herb medicine extensively used in many areas. The plants from …