The studies of psychedelics, especially psychedelic tryptamines like psilocybin, are rapidly
gaining interest in neuroscience research. Much of this interest stems from recent clinical …

Background: Widespread protein aggregation occurs in the living system under stress or
during aging, owing to disturbance of endoplasmic reticulum (ER) proteostasis. Many …

Depression and cognitive disorders are diseases with complex and not-fully understood
etiology. Unfortunately, the COVID-19 pandemic dramatically increased the prevalence of …

Sigma-1 receptors are molecular chaperones that may act as pathological mediators and
targets for novel therapeutic applications in neurodegenerative diseases. Accumulating …

Developmental and epileptic encephalopathies (DEEs) are complex conditions
characterized primarily by seizures associated with neurodevelopmental and motor deficits …

We investigated the anti-inflammatory and analgesic effects of quercetin in monosodium
urate crystals (MSU)-induced gout arthritis, and the sensitivity of quercetin effects to …

A growing body of studies indicated that exosomes are one of vital players in pathological
process of neuropsychiatric diseases, but their role in major depressive disorder (MDD) …

A large body of evidence indicates that sigma-1 receptors (Sig-1R) are important drug
targets for a number of neuropsychiatric disorders. Sig-1Rs are enriched in central nervous …

Background: Efferocytosis of apoptotic neurons by macrophages is essential for the
resolution of inflammation and for neuronal protection from secondary damage. It is known …

The sigma-1 receptor (Sig-1R) is a chaperone receptor that primarily resides at the
mitochondria-associated endoplasmic reticulum (ER) membrane (MAM) and acts as a …