Autophagy is fundamental for cell and organismal health. Two types of autophagy are
conserved in eukaryotes: macroautophagy and microautophagy. During macroautophagy …

Soluble N-ethylmaleimide-sensitive factor attachment protein receptors (SNAREs) are a
family of small conserved eukaryotic proteins that mediate membrane fusion between …

Autophagy is a highly conserved lysosomal degradation pathway active at basal levels in all
cells. However, under stress conditions, such as a lack of nutrients or trophic factors, it works …

The late endosomes/endo‐lysosomes of vertebrates contain an atypical phospholipid,
lysobisphosphatidic acid (LBPA)(also termed bis [monoacylglycero] phosphate [BMP]) …

▪ Abstract Disparate biological processes involve fusion of two membranes into one and
fission of one membrane into two. To formulate the possible job description for the proteins …

Tethering factors have been shown to interact with Rabs and SNAREs and, more recently,
with coat proteins. Coat proteins are required for cargo selection and membrane …

Fungal vacuoles are acidic organelles with degradative and storage capabilities that have
many similarities to mammalian lysosomes and plant vacuoles. In the past several years …

Nascent phagosomes must undergo a series of fusion and fission reactions to acquire the
microbicidal properties required for the innate immune response. Here we demonstrate that …

Subcellular compartmentalization, cell growth, hormone secretion and neurotransmission
require rapid, targeted, and regulated membrane fusion. Fusion entails extensive lipid …

Abstract On demand, rapid Ca2+-triggered homotypic and exocytic membrane-fusion events
are required to repair a torn plasma membrane, and we propose that this emergency-based …