Mechanical force plays an important role in the regulation of bone remodelling in intact bone
and bone repair. In vitro, bone cells demonstrate a high responsiveness to mechanical …

In this study the literature dealing with experimental cranio-facial distraction osteogenesis
(DO) was reviewed. A PUBMED search (National Library of Medicine [NCBI] revised 1 April …

The role of angiogenesis during mechanically induced bone formation is incompletely
understood. The relationship between the mechanical environment, angiogenesis, and …

We investigated the effects of two types of cyclic tensile strain, continuous and rest inserted,
on osteogenic differentiation of human adipose-derived adult stem cells (hASCs). The …

BACKGROUND: Deferoxamine (DFO) is an iron-chelating agent that has also been shown
to increase angiogenesis. We hypothesize that the angiogenic properties of DFO will …

BACKGROUND: Distraction osteogenesis is a valuable clinical tool; however the molecular
mechanisms governing successful distraction remain unknown. We have used a uniaxial in …

The conservative nature of animal evolution makes animal models the ideal tool for learning
about human biology. The Handbook of Laboratory Animal Science, Second Edition: Animal …

Bone has the capacity to regenerate in response to injury. During distraction osteogenesis,
the renewal of bone is enhanced by gradual stretching of the soft connective tissues in the …

Three‐dimensional finite element (FE) analyses were performed to characterize the local
mechanical environment created within the tissue regenerate during mandibular distraction …

We analyzed mechanobiological influences on successful distraction osteogenesis (DO).
Mandibular distraction surgeries were performed on 15 adult male Sprague–Dawley rats …