Traumatic brain injury in elderly population: a global systematic review and meta-analysis of in-hospital mortality and risk factors among 2.22 million individuals

Z Ma, Z He, Z Li, R Gong, J Hui, W Weng, X Wu… - Ageing research …, 2024 - Elsevier
Background Traumatic brain injury (TBI) among elderly individuals poses a significant global
health concern due to the increasing ageing population. Methods We searched PubMed …

[HTML][HTML] Systemic immune response in young and elderly patients after traumatic brain injury

M Magatti, F Pischiutta, F Ortolano, A Pasotti… - Immunity & …, 2023 - Springer
Background Traumatic brain injury (TBI) is a leading cause of death and long-term disability
worldwide. In addition to primary brain damage, systemic immune alterations occur, with …

Long-term multidomain patterns of change after traumatic brain injury: a TRACK-TBI LONG study

BL Brett, N Temkin, JK Barber, DO Okonkwo, M Stein… - Neurology, 2023 - AAN Enterprises
Background and Objectives Traumatic brain injury (TBI) may be a chronic condition carrying
risk of future sequelae; few prospective studies examine long-term postinjury outcomes. We …

Quality of life and psychological health after mild traumatic brain injury in older people: Three-and six-month follow up

CH Hume, B Mitra, BJ Wright, GJ Kinsella - Brain injury, 2023 - Taylor & Francis
Objectives Examine quality of life (QoL) and psychological health after mild traumatic brain
injury (mTBI) in older people (65+ years) at 3-and 6-month follow-up and explore which …

[HTML][HTML] Neuroworsening in the emergency department is a predictor of traumatic brain injury intervention and outcome: a TRACK-TBI pilot study

JK Yue, N Krishnan, JH Kanter, H Deng… - Journal of clinical …, 2023 - mdpi.com
Introduction: Neuroworsening may be a sign of progressive brain injury and is a factor for
treatment of traumatic brain injury (TBI) in intensive care settings. The implications of …

Study protocol for investigating the clinical performance of an automated blood test for glial fibrillary acidic protein and ubiquitin carboxy-terminal hydrolase L1 blood …

A Lagares, JF Payen, P Biberthaler, MA Poca… - BMJ open, 2023 - bmjopen.bmj.com
Introduction Two blood brain-derived biomarkers, glial fibrillar acidic protein (GFAP) and
ubiquitin carboxy-terminal hydrolase L1 (UCH-L1), can rule out intracranial lesions in …

[HTML][HTML] Clinical complications after a traumatic brain injury and its relation with brain biomarkers

O Yuguero, M Bernal, J Farré, M Martinez-Alonso… - Scientific Reports, 2023 - nature.com
We aimed to find out which are the most frequent complications for patients who suffer a
traumatic brain injury (TBI) and its relation with brain biomarker levels. We conducted a …

Impaired oligodendrogenesis in the white matter of aged mice following diffuse traumatic brain injury

G Michalettos, F Clausen, I Özen, K Ruscher… - Glia, 2024 - Wiley Online Library
Senescence is a negative prognostic factor for outcome and recovery following traumatic
brain injury (TBI). TBI‐induced white matter injury may be partially due to oligodendrocyte …

Bradykinin 2 Receptors Mediate Long-Term Neurocognitive Deficits After Experimental Traumatic Brain Injury

AC Wehn, I Khalin, S Hu, BN Harapan, X Mao… - Journal of …, 2024 - liebertpub.com
The kallikrein–kinin system is one of the first inflammatory pathways to be activated following
traumatic brain injury (TBI) and has been shown to exacerbate brain edema formation in the …

[HTML][HTML] Good Health-Related Quality of Life in Older Patients One Year after mTBI despite Incomplete Recovery: An Indication of the Disability Paradox?

SM Coffeng, AE Abdulle, HJ van der Horn… - Journal of Clinical …, 2024 - mdpi.com
Background: Older adults (OAs) with mild traumatic brain injury (OA-mTBI) are a growing
population, but studies on long-term outcomes and quality of life are scarce. Our aim was to …