The reproducibility crisis in the age of digital medicine

A Stupple, D Singerman, LA Celi - NPJ digital medicine, 2019 - nature.com
If anyone doubts the explosive growth of interest in digital medicine, consider a recent
conference and workshop in Beijing, jointly organized by the People's Liberation Army …

How to design preclinical studies in nanomedicine and cell therapy to maximize the prospects of clinical translation

JPA Ioannidis, BYS Kim, A Trounson - Nature biomedical engineering, 2018 - nature.com
The clinical translation of promising products, technologies and interventions from the
disciplines of nanomedicine and cell therapy has been slow and inefficient. In part …

Nextflow enables reproducible computational workflows

P Di Tommaso, M Chatzou, EW Floden, PP Barja… - Nature …, 2017 - nature.com
The increasing complexity of readouts for omics analyses goes hand-in-hand with concerns
about the reproducibility of experiments that analyze'big data'1, 2, 3. When analyzing very …

AiiDA 1.0, a scalable computational infrastructure for automated reproducible workflows and data provenance

SP Huber, S Zoupanos, M Uhrin, L Talirz, L Kahle… - Scientific data, 2020 - nature.com
The ever-growing availability of computing power and the sustained development of
advanced computational methods have contributed much to recent scientific progress …

Why and how to account for sex and gender in brain and behavioral research

L Eliot, AK Beery, EG Jacobs, HF LeBlanc… - Journal of …, 2023 - Soc Neuroscience
Long overlooked in neuroscience research, sex and gender are increasingly included as
key variables potentially impacting all levels of neurobehavioral analysis. Still, many …

Systematic integration of biomedical knowledge prioritizes drugs for repurposing

DS Himmelstein, A Lizee, C Hessler, L Brueggeman… - Elife, 2017 - elifesciences.org
The ability to computationally predict whether a compound treats a disease would improve
the economy and success rate of drug approval. This study describes Project Rephetio to …

The future of academic publishing

A Ahmed, A Al-Khatib, Y Boum, H Debat… - Nature human …, 2023 - nature.com
Academic publishing is the backbone of science dissemination––but is the current system fit
for purpose? We asked a diverse group of scientists to comment on the future of publishing …

COMPare: a prospective cohort study correcting and monitoring 58 misreported trials in real time

B Goldacre, H Drysdale, A Dale, I Milosevic, E Slade… - Trials, 2019 - Springer
Background Discrepancies between pre-specified and reported outcomes are an important
source of bias in trials. Despite legislation, guidelines and public commitments on correct …

Contextualising harm in the framework of research misconduct. Findings from discourse analysis of scientific publications

V Petousi, E Sifaki - International Journal of Sustainable …, 2020 - inderscienceonline.com
This article reports on research, which deals with dimensions of harm resulting from
research misconduct, in articles published in scientific journals. An appropriate sample of …

[图书][B] Reproducibility and replicability in science

National Academies of Sciences, Policy, Global Affairs… - 2019 - books.google.com
One of the pathways by which the scientific community confirms the validity of a new
scientific discovery is by repeating the research that produced it. When a scientific effort fails …