Drug pharmacokinetics in the obese population: challenging common assumptions on predictors of obesity-related parameter changes
T Zhang, EHJ Krekels, C Smit… - Expert opinion on drug …, 2022 - Taylor & Francis
Introduction Obesity is associated with many physiological changes. We review available
evidence regarding five commonly accepted assumptions to a priori predict the impact of …
evidence regarding five commonly accepted assumptions to a priori predict the impact of …
Dosing in children: a critical review of the pharmacokinetic allometric scaling and modelling approaches in paediatric drug development and clinical settings
I Mahmood - Clinical pharmacokinetics, 2014 - Springer
It should be recognized that children are not small adults, hence dosing in children should
not be a 'small adult dose'. A mean population dose in all age groups is just an average …
not be a 'small adult dose'. A mean population dose in all age groups is just an average …
Association of busulfan exposure with survival and toxicity after haemopoietic cell transplantation in children and young adults: a multicentre, retrospective cohort …
IH Bartelink, A Lalmohamed, EML van Reij… - The Lancet …, 2016 - thelancet.com
Background Intravenous busulfan combined with therapeutic drug monitoring to guide
dosing improves outcomes after allogeneic haemopoietic cell transplantation (HCT). The …
dosing improves outcomes after allogeneic haemopoietic cell transplantation (HCT). The …
Association between anti-thymocyte globulin exposure and CD4+ immune reconstitution in paediatric haemopoietic cell transplantation: a multicentre, retrospective …
R Admiraal, C van Kesteren… - The Lancet …, 2015 - thelancet.com
Background Anti-thymocyte globulin (ATG) was introduced into the conditioning regimen in
haemopoietic cell transplantation (HCT) to prevent graft-versus-host-disease (GvHD) and …
haemopoietic cell transplantation (HCT) to prevent graft-versus-host-disease (GvHD) and …
Excellent T-cell reconstitution and survival depend on low ATG exposure after pediatric cord blood transplantation
R Admiraal, CA Lindemans… - Blood, The Journal …, 2016 - ashpublications.org
Successful immune reconstitution (IR) is associated with improved outcomes following
pediatric cord blood transplantation (CBT). Usage and timing of anti–thymocyte globulin …
pediatric cord blood transplantation (CBT). Usage and timing of anti–thymocyte globulin …
Busulfan in infant to adult hematopoietic cell transplant recipients: a population pharmacokinetic model for initial and Bayesian dose personalization
Purpose: Personalizing intravenous busulfan doses to a target plasma concentration at
steady state (C ss) is an essential component of hematopoietic cell transplantation (HCT) …
steady state (C ss) is an essential component of hematopoietic cell transplantation (HCT) …
Allometric scaling of clearance in paediatric patients: when does the magic of 0.75 fade?
EAM Calvier, EHJ Krekels, PAJ Välitalo… - Clinical …, 2017 - Springer
Allometric scaling on the basis of bodyweight raised to the power of 0.75 (AS0. 75) is
frequently used to scale size-related changes in plasma clearance (CL p) from adults to …
frequently used to scale size-related changes in plasma clearance (CL p) from adults to …
Clarifying busulfan metabolism and drug interactions to support new therapeutic drug monitoring strategies: a comprehensive review
AL Myers, JD Kawedia, RE Champlin… - Expert opinion on …, 2017 - Taylor & Francis
ABSTRACT Introduction: Busulfan (Bu) is an alkylating agent with a limited therapeutic
margin and exhibits inter-patient variability in pharmacokinetics (PK). Despite decades of …
margin and exhibits inter-patient variability in pharmacokinetics (PK). Despite decades of …
Drug disposition in obesity: toward evidence-based dosing
CAJ Knibbe, MJE Brill, A van Rongen… - Annual review of …, 2015 - annualreviews.org
Obesity and morbid obesity are associated with many physiological changes affecting
pharmacokinetics, such as increased blood volume, cardiac output, splanchnic blood flow …
pharmacokinetics, such as increased blood volume, cardiac output, splanchnic blood flow …