Foot-and-mouth disease (FMD) is a highly contagious disease of cloven-hoofed animals.
The disease was initially described in the 16th century and was the first animal pathogen …

Current understanding of the molecular basis of pathogenesis of foot-and-mouth disease
(FMD) has been achieved through over 100 years of study into the biology of the etiologic …

The dynamics of proliferation of large genomic RNA molecules which carry the polio virus
are investigated using new techniques. Genetic variation and identity conservation of …

Human enteroviruses have traditionally been typed according to neutralization serotype.
This procedure is limited by the difficulty in culturing some enteroviruses, the availability of …

We describe a sensitive, internally controlled method for comparing the genetic adaptability
and relative fitness of virus populations in constant or changing host environments. Certain …

Poliomyelitis has afflicted humankind since antiquity, and for nearly a century now, we have
known the causative agent, poliovirus. This pathogen is an enterovirus that in recent history …

The poliovirus P2/P712 strain is an attenuated virus that is closely related to the type 2 Sabin
vaccine strain. By using a mouse model for poliomyelitis, sequences responsible for …

Production of live attenuated oral poliomyelitis vaccine (OPV) requires rigorous
neurovirulence safety testing of each vaccine lot, currently carried out in monkeys. It has …

A base change from C to U at position 472 of the 5'noncoding region of the poliovirus
genome is known to be a major determinant of attenuation in the P3/Sabin vaccine strain. To …

Maturation of picornaviruses involves assembly of a" provirion," which undergoes an
autocatalytic cleavage of VP0 to VP2 plus VP4. RNA transcripts from a cDNA clone of …