Proteostasis refers to all the processes that maintain the correct expression level, location,
folding and turnover of proteins, essential to organismal survival. Both inside cells and in …

The multifunctional protein clusterin (CLU) was first described in 1983 as a secreted
glycoprotein present in ram rete testis fluid that enhanced aggregation ('clustering') of a …

Aqueous humor (AH) can be easily and safely used to evaluate disease-specific biomarkers
in ocular disease. The aim of this study was to identify specific proteins biomarkers in the AH …

Background ApoJ/clusterin is a multifunctional protein highly expressed in the brain. The
implication of ApoJ in β-amyloid (Aβ) fibrillization and clearance in the context of Alzheimer's …

Abstract Background The Tibial dyschondroplasia (TD) in fast-growing chickens is mainly
caused by improper blood circulation. The exact mechanism underlying angiogenesis and …

Retinoblastoma (RB) is the most common malignant intraocular tumor in early childhood.
Imminent chemotherapy resistance diminishes the clinical-therapeutic options and …

Purpose: To study the role of lysine-specific demethylase 1 (LSD1) in retinoblastoma (RB)
growth and to determine whether the LSD1 inhibitor SP2509 can inhibit RB progression …

Cerebral amyloid angiopathy (CAA) refers to beta-amyloid (Aβ) deposition in brain vessels
and is clinically the main cause of lobar intracerebral hemorrhage (ICH). Aβ can also …

Background Clusterin (Clu) is a stress-responding protein with multiple biological functions.
Our preliminary microarray studies show that clusterin was prominently upregulated in …

Recurrence and metastasis are the two leading causes of poor prognosis in patients with
hepatocellular carcinoma (HCC). Secreted clusterin (sCLU) is a stress‑induced chaperone …