Since 1984, when paclitaxel was approved by the FDA for the treatment of advanced
ovarian carcinoma, taxanes have been widely used as microtubule-targeting antitumor …

Intense interest in the'Warburg effect'has been revived by the discovery that hypoxia-
inducible factor 1 (HIF1) reprogrammes pyruvate oxidation to lactic acid conversion; lactic …

The emergence of OpenAI's ChatGPT has put intense spotlight on Generative AI (Gen-AI)
systems and their possible impacts on Academic integrity. This paper provides an overview …

Na+/H+ exchangers play pivotal roles in the control of cell and tissue pH by mediating the
electroneutral exchange of Na+ and H+ across cellular membranes. They belong to an …

Cancer is a metabolic disease and the solution of two metabolic equations: to produce
energy with limited resources and to fulfill the biosynthetic needs of proliferating cells. Both …

Cancer cells acquire an unusual glycolytic behavior relative, to a large extent, to their
intracellular alkaline pH (pH i). This effect is part of the metabolic alterations found in most, if …

A distinguishing phenotype of solid tumors is the presence of an alkaline cellular feature
despite the surrounding acidic microenvironment. This phenotypic characteristic of tumors …

Much effort is currently devoted to developing patient-specific cancer therapy based on
molecular characterization of tumors. In particular, this approach seeks to identify driver …

Introduction: The dysregulation of pH by cancerous cells of solid tumors is able to create a
unique milieu that is in favor of progression, invasion and metastasis as well as chemo …

Looked at from the genetic point-of-view cancer represents a daunting and, frankly,
confusing multiplicity of diseases (at least 100) that require an equally large variety of …