Adipose tissues are dynamic tissues that play crucial physiological roles in maintaining
health and homeostasis. Although white adipose tissue and brown adipose tissue are …

Understanding adipogenesis, the process of adipocyte development, may provide new ways
to treat obesity and related metabolic diseases. Adipogenesis is controlled by coordinated …

Cell-type-specific gene expression is physiologically modulated by the binding of
transcription factors to genomic enhancer sequences, to which chromatin modifiers such as …

Brown adipose tissue can expend large amounts of energy, and therefore increasing its size
or activity is a promising therapeutic approach to combat metabolic disease. In humans …

Complex interaction between genetics, epigenetics, environment, and nutrition affect the
physiological activities of adipose tissues and their dysfunctions, which lead to several …

Brown adipose tissue (BAT) dissipates energy to produce heat. Thus, it has the potential to
regulate body temperature by thermogenesis. For the last decade, BAT has been in the …

Adipose tissue, once viewed as an inert organ of energy storage, is now appreciated to be a
central node for the dynamic regulation of systemic metabolism. There are three general …

Metabolic pathways dynamically regulate tissue development and maintenance. However,
the mechanisms that govern the metabolic adaptation of stem or progenitor cells to their …

The ability to generate thermogenic fat could be a targeted therapy to thwart obesity and
improve metabolic health. Brown and beige adipocytes are two types of thermogenic fat …

The neoplastic stromal cells of giant cell tumor of bone (GCTB) carry a mutation in H3F3A,
leading to a mutant histone variant, H3. 3-G34W, as a sole recurrent genetic alteration. We …