Chitin and chitosan are two related polysaccharides that provide important structural stability
to fungal cell walls. Often embedded deeply within the cell wall structure, these molecules …

Limited antifungal diversity and availability are growing problems for the treatment of fungal
infections in the face of increasing drug resistance. The echinocandins, one of the newest …

The ability for cells to maintain homeostasis in the presence of extracellular stress is
essential for their survival. Stress adaptations are especially important for microbial …

Cellular responses to external stress allow microorganisms to adapt to a vast array of
environmental conditions, including infection sites. The molecular mechanisms behind these …

Cryptococcus neoformans causes cryptococcal meningoencephalitis, a disease that kills
more than 180,000 people annually. Contributing to its success as a fungal pathogen is its …

Cryptococcus neoformans infections are significant causes of morbidity and mortality among
AIDS patients and the third most common invasive fungal infection in organ transplant …

Cryptococcus gattii is an etiologic agent of cryptococcosis, a potentially fatal disease that
affects humans and animals. The successful infection of mammalian hosts by cryptococcal …

During mammalian colonization and infection, microorganisms must be able to rapidly
sense and adapt to changing environmental conditions including alterations in extracellular …

Cryptococcus neoformans kills 200,000 people worldwide each year. After inhalation, this
environmental yeast proliferates either extracellularly or within host macrophages. Under …

The yeast-like pathogen Cryptococcus gattii is an etiological agent of cryptococcosis. The
major cryptococcal virulence factor is the polysaccharide capsule, which is composed of …