T cells are crucial for immune functions to maintain health and prevent disease. T cell
development occurs in a stepwise process in the thymus and mainly generates CD4+ and …

T lymphocytes (T cells) are divided into two functionally different subgroups the CD4+ T
helper cells (Th) and the CD8+ cytotoxic T lymphocytes (CTL). Adequate CD4 and CD8 T …

Abstract CD4+ effector lymphocytes (Teff) are traditionally classified by the cytokines they
produce. To determine the states that Teff cells actually adopt in frontline tissues in vivo, we …

Tumor-infiltrating regulatory T lymphocytes (Treg) can suppress effector T cells specific for
tumor antigens. Deeper molecular definitions of tumor-infiltrating-lymphocytes could thus …

CD4+ T helper (TH) cells and regulatory T (Treg) cells that respond to common allergens
play an important role in driving and dampening airway inflammation in patients with …

Abstract Coronavirus disease 2019 (COVID-19) is a respiratory infectious disease caused
by the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). COVID-19 is …

Allergic diseases are on the rise in the Western world and well-known allergy-protecting and-
driving factors such as microbial and dietary exposure, pollution and smoking mediate their …

High parameter imaging is an important tool in the life sciences for both discovery and
healthcare applications. Imaging Mass Cytometry (IMC) and Multiplexed Ion Beam Imaging …

The outcome of Mycobacterium tuberculosis (Mtb) infection ranges from a complete
pathogen clearance through asymptomatic latent infection (LTBI) to active tuberculosis (TB) …

Background—Inappropriately sustained inflammation is a hallmark of chronic ischemic heart
failure (HF); however, the pathophysiological role of T lymphocytes is unclear. Methods and …