Diffuse midline gliomas and posterior fossa type A ependymomas contain the recurrent
histone H3 lysine 27 (H3 K27M) mutation and express the H3 K27M-mimic EZHIP (CXorf67) …

After decades of research, our knowledge of the complexity of cancer mechanisms,
elegantly summarized as 'hallmarks of cancer', is expanding, as are the therapeutic …

Our understanding of cancer genomes has allowed for the integration of molecular data into
histopathological classifications for routine stratification of patients. In the last 10–15 years …

Lysine 27-to-methionine (K27M) mutations in the H3. 1 or H3. 3 histone genes are
characteristic of pediatric diffuse midline gliomas (DMGs). These oncohistone mutations …

Maternally synthesized products play critical roles in the development of offspring. A premier
example is the Caenorhabditis elegans H3K36 methyltransferase MES-4, which is essential …

Abstract Mutant isocitrate dehydrogenase 1/2 (mIDH1/2) gain a novel function for the
conversion of α-ketoglutarate (α-KG) to oncometabolite R-2-hydroxyglutarate (R-2-HG). Two …

Epigenetic inheritance refers to the transmission of phenotypes across generations without
affecting the genomic DNA sequence. Even though it has been documented in many …

Simple Summary Pediatric high-grade gliomas (pHGGs) are the leading cause of mortality in
pediatric neuro-oncology, due in great part to treatment resistance driven by complex DNA …

Forward genetics is a powerful tool to unravel molecular mechanisms of diverse biological
processes. The success of genetic screens primarily relies on the ease of genetic …

Histone H3. 3 is a replication-independent variant of histone H3 with important roles in
development, differentiation, and fertility. Here, we show that loss of H3. 3 results in …