Normal eating behaviour is coordinated by the tightly regulated balance between intestinal
and extra-intestinal homeostatic and hedonic mechanisms. By contrast, food addiction is a …

5-HT receptors expressed throughout the human body are targets for established
therapeutics and various drugs in development. Their diversity of structure and function …

The initial discovery that ob/ob mice become obese because of a recessive mutation of the
leptin gene has been crucial to discover the melanocortin pathway to control appetite. In the …

Since our review of central 5-HT receptors and their function twenty years ago, no new 5-HT
receptor has been discovered and there is little evidence that this situation will change in the …

Serotonin is perhaps best known as a neurotransmitter that modulates neural activity and a
wide range of neuropsychological processes, and drugs that target serotonin receptors are …

Background Lorcaserin is a selective serotonin 2C receptor agonist that could be useful in
reducing body weight. Methods In this double-blind clinical trial, we randomly assigned …

Serotonin has been implicated in the control of satiety for almost four decades. Historically,
the insight that the appetite suppressant effect of fenfluramine is linked to serotonin has …

Obesity is a disorder of lipid metabolism and continues to be a global problem, ranking fifth
for deaths worldwide. It also leads to diabetes, cardiovascular disorders, musculoskeletal …

Context: Lorcaserin is a novel selective agonist of the serotonin 2C receptor. Objective: Our
objective was to evaluate the effects of lorcaserin on body weight, cardiovascular risk …

Obesity is a global epidemic that contributes to a number of health complications including
cardiovascular disease, type 2 diabetes, cancer and neuropsychiatric disorders …