The BK virus (BKPyV) is a member of the Polyomaviridae family first isolated in 1971. BKPyV
causes frequent infections during childhood and establishes persistent infections with …

The single-stranded DNA binding proteins (SSBs) are required to maintain the integrity of
the genome in all organisms. Replication protein A (RPA) is a nuclear SSB protein found in …

BK polyomavirus (BKPyV) is an emerging pathogen whose reactivation causes severe
disease in transplant patients. Unfortunately, there is no specific anti-BKPyV treatment …

About 40 years ago, the large and small tumor antigens (LT-Ag and sT-Ag) of the
polyomavirus (PyVs) simian vacuolating virus 40 have been identified and characterized. To …

BKPyV and JCPyV are closely related, ubiquitous human pathogens that cause disease in
immunocompromised patients. The DNA sequence of the regulatory regions distinguishes …

Most viral gene products function inside cells in the presence of various host proteins,
nucleic acids, and lipids. Thus, viral gene products come into direct contact with these …

In the past three years, remarkable discoveries have added three new human
polyomaviruses (KI virus (KIV), WU virus (WUV) and Merkel cell virus (MCV)) to a class that …

BK polyomavirus (BKPyV) infection causes various diseases in immunocompromised
patients. Cells from human lung and kidney were infected with BKPyV and treated with …

All members of the polyomavirus family encode a large T antigen (LT) protein that plays
essential roles in viral DNA replication, regulation of viral gene expression, and the …

ABSTRACT BK polyomavirus (BKV) establishes persistent, low-level, and asymptomatic
infections in most humans and causes polyomavirus-associated nephropathy (PVAN) and …