Molecular inputs to chromatin via cellular metabolism are modifiers of the epigenome. These
inputs—which include both nutrient availability as a result of diet and growth factor signalling …

Ketone bodies play significant roles in organismal energy homeostasis, serving as oxidative
fuels, modulators of redox potential, lipogenic precursors, and signals, primarily during …

Regulatory myeloid immune cells, such as myeloid-derived suppressor cells (MDSCs),
populate inflamed or cancerous tissue and block immune cell effector functions. The lack of …

Prospective molecular targets and therapeutic applications for ketone body metabolism
have increased exponentially in the past decade. Initially considered to be restricted in …

Alzheimer's disease (AD) is a neurodegenerative disease characterized by progressive
cognitive impairment and neuroinflammation. Recent research has revealed the crucial role …

Methylglyoxal (MG) is a ubiquitous metabolite that spontaneously reacts with biopolymers
forming advanced glycation end-products (AGEs). AGEs are strongly associated with aging …

Citrate, a substance being related to de novo fatty acid synthesis and tricarboxylic acid
(TCA) cycle, has a pivotal role in cell survival. However, the molecular mechanisms that …

The glyoxalase system is critical for the detoxification of advanced glycation end-products
(AGEs). AGEs are toxic compounds resulting from the non-enzymatic modification of …

Methylglyoxal (MGO), a reactive metabolite byproduct of glucose metabolism, is known to
form a variety of posttranslational modifications (PTMs) on nucleophilic amino acids. For …

Direct regulation of gene expression may occur in-vivo via through ketone body-mediated
histone modifications during adherence to low-carbohydrate diets, fasting ketosis …