SARS-CoV-2 and HSV-1 Induce Amyloid Aggregation in Human CSF Resulting in Drastic Soluble Protein Depletion

W Christ, S Kapell, MJ Sobkowiak… - ACS Chemical …, 2024 - ACS Publications
The corona virus (SARS-CoV-2) pandemic and the resulting long-term neurological
complications in patients, known as long COVID, have renewed interest in the correlation …

[HTML][HTML] 骨髓红系比例≥ 50% 的骨髓增生异常综合征患者临床特征及预后分析

曾燕平, 李冰, 秦铁军, 徐泽锋, 曲士强… - Chinese Journal of …, 2024 - pmc.ncbi.nlm.nih.gov
目的分析骨髓红系比例≥ 50% 的骨髓增生异常综合征(MDS-E) 患者临床和实验室特征及预后.
方法收集2014 年5 月至2023 年6 月于中国医学科学院血液病医院确诊的1 436 例MDS …

Inflammatory Mesenchymal Stromal Cells and IFN-responsive T cells are key mediators of human bone marrow niche remodeling in CHIP and MDS

KD Prummel, K Woods, M Kholmatov, E Schmitt… - bioRxiv, 2024 - biorxiv.org
Somatic mutations in hematopoietic stem/progenitor cells (HSPCs) can lead to clonal
hematopoiesis of indeterminate potential (CHIP), potentially progressing to myelodysplastic …

SF3B1-mutant mis-splicing of UBA1 confers a targetable therapeutic vulnerability through UBA1 inhibition

J Thier, S Hofmann, K Kirchhof, G Todisco… - bioRxiv, 2024 - biorxiv.org
SF3B1 mutation-driven myelodysplastic syndromes (MDS-SF3B1) arise due to somatic
mutation in the splicing factor SF3B1 gene. SF3B1 mutations induce RNA mis-splicing and …