Nutrient signaling through insulin/IGF-1 was the first pathway demonstrated to regulate
ageing and age-related disease in model organisms. Pharmacological or dietary …

Sarcopenia, defined as age‐associated decline of muscle mass and function, is a risk factor
for mortality and disability, and comorbid with several chronic diseases such as type II …

Background: The vast geographical expansion of novel coronavirus and an increasing
number of COVID-19 affected cases have overwhelmed health and public health services …

Breast cancer is the most frequent malignancy among women. It is a heterogeneous disease
with different subtypes defined by its hormone receptor. A hormone receptor is mainly …

Introduction: Renal Cell Carcinoma is a common type of renal cancer-causing deaths
worldwide which is characterized by sustained angiogenesis. VEGF and its receptors play a …

The progression of lung cancer is associated with inactivation of programmed cell death
protein 1, abbreviated as PD-1 which regulates the suppression of the body's immune …

Colorectal cancer possesses the third highest diagnostic rate and is the second leading
cause of cancer death in the USA as reported by NIH. Epidermal Growth Factor Receptor …

Drug discovery is one of the most complicated processes and establishment of a single drug
may require multidisciplinary attempts to design efficient and commercially viable drugs. The …

Multiple cytokines play a pivotal role in the pathogenesis of Rheumatoid Arthritis by inducing
intracellular signaling and it is known that the members of the Janus kinase (JAK) family are …

Juvenile idiopathic arthritis (JIA) is a heterogeneous disease characterized by the arthritis of
unknown origin and IL6 is a known target for JIA. 20 known inhibitors towards IL-6 were …