Membrane protrusions at the leading edge of cells, known as lamellipodia, drive cell
migration in many normal and pathological situations. Lamellipodial protrusion is powered …

The Arp2/3 complex is an evolutionary conserved molecular machine that generates
branched actin networks. When activated, the Arp2/3 complex contributes the actin …

Actin assembly provides force for a multitude of cellular processes. Compared to actin-
assembly-based force production during cell migration, relatively little is understood about …

Protein kinase C and casein kinase substrate in neurons (PACSINs), or syndapins (synaptic
dynamin‐associated proteins), are a family of proteins involved in the regulation of cell …

Members of the Bin/amphiphysin/Rvs (BAR) domain protein superfamily are involved in
membrane remodeling in various cellular pathways ranging from endocytic vesicle and T …

Importance of the field: The last 10 years have seen a dramatic growth in understanding and
controlling how complex, drug-loaded (nano) structures, as well as pathogens, or …

Endocytosis of receptors at the plasma membrane is controlled by a complex mechanism
that includes clathrin, adaptors, and actin regulators. Many of these proteins are conserved …

Cellular adhesion, motility, endocytosis, exocytosis and cytokinesis involve the coordinated
reorganization of the cytoskeleton and of the plasma membrane. The 'Pombe Cdc15 …

Formins represent a major branch of actin nucleators along with the Arp2/3 complex, Spire
and Cordon-bleu. Formin-mediated actin nucleation requires the formin homology 2 domain …

Abstract The Pombe Cdc15 Homology (PCH) proteins have emerged in many species as
important coordinators of signaling pathways that regulate actomyosin assembly and …